Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes

doi:10.1038/srep42434

	Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes
	Wei, Guangzheng 1; Tan, Dongdong 1; Chen, Chunmei 1; Tong, Qingyi 1; Li, Xiao-Nian 2; Huang, Jinfeng 1; Liu, Junjun 1; Xue, Yongbo 1; Wang, Jianping 1; Luo, Zengwei 1; Zhu, Hucheng 1; Zhang, Yonghui 1
	2017-02-13
发表期刊	SCIENTIFIC REPORTS
卷号	7 期号:1 页码:42434
摘要	Two new tetracyclic cytochalasans, flavichalasines A and B (1 and 2), three new pentacyclic cytochalasans, flavichalasines C-E (3-5), and eight new tricyclic cytochalasans, flavichalasines F-M (6-13), together with eight known analogues (14-21), were isolated from the solid culture of Aspergillus flavipes. Structures of these new compounds were elucidated on the basis of extensive spectroscopic analyses including 1D, 2D NMR and HRESIMS data. Their absolute configurations were determined by comparison of their experimental ECD with either computed ECD or experimental ECD spectrum of known compound. The structure and absolute configuration of 2 were further determined by X-ray crystallographic diffraction. Flavichalasine A (1) represents the first example of cytochalasan with a terminal double bond at the macrocyclic ring and flavichalasine E (5) is the only cytochalasan with an a-oriented oxygen-bridge in D ring. These new compounds were evaluated for their cytotoxic activities against seven human cancer cell lines, of which, 6 and 14 displayed moderate inhibitory activities against tested cell lines. In addition, compounds 6 and 14 induced apoptosis of HL60 cells by activation of caspase-3 and degradation of PARP.
DOI	10.1038/srep42434
收录类别	SCI
语种	英语
WOS记录号	WOS:000394155400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/41900
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Wei, Guangzheng,Tan, Dongdong,Chen, Chunmei,et al. Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes[J]. SCIENTIFIC REPORTS,2017,7(1):42434.
APA	Wei, Guangzheng.,Tan, Dongdong.,Chen, Chunmei.,Tong, Qingyi.,Li, Xiao-Nian.,...&Zhang, Yonghui.(2017).Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes.SCIENTIFIC REPORTS,7(1),42434.
MLA	Wei, Guangzheng,et al."Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes".SCIENTIFIC REPORTS 7.1(2017):42434.

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