Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora
Xiao, Wei-Lie1; Wang, Rui-Rui2; Zhao, Wei1; Tian, Ren-Rong2; Shang, Shan-Zhai1; Yang, Liu-Meng2; Yang, Jian-Hong1; Pu, Jian-Xin1; Zheng, Yong-Tang2; Sun, Han-Dong1
2010-05-01
Source PublicationARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
Volume33Issue:5Pages:697-701
Abstract

This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 similar to 20.4 mu g/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.

KeywordSchisandra Rubriflora Lignan Nmr Cd Spectrum Anti-hiv-1 Activity
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1007/s12272-010-0508-7
Indexed BySCI
Language英语
WOS IDWOS:000278112400009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4176
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Xiao, Wei-Lie,Wang, Rui-Rui,Zhao, Wei,et al. Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora[J]. ARCHIVES OF PHARMACAL RESEARCH,2010,33(5):697-701.
APA Xiao, Wei-Lie.,Wang, Rui-Rui.,Zhao, Wei.,Tian, Ren-Rong.,Shang, Shan-Zhai.,...&Sun, Han-Dong.(2010).Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora.ARCHIVES OF PHARMACAL RESEARCH,33(5),697-701.
MLA Xiao, Wei-Lie,et al."Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora".ARCHIVES OF PHARMACAL RESEARCH 33.5(2010):697-701.
Files in This Item: Download All
File Name/Size DocType Version Access License
201112280006.pdf(352KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xiao, Wei-Lie]'s Articles
[Wang, Rui-Rui]'s Articles
[Zhao, Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xiao, Wei-Lie]'s Articles
[Wang, Rui-Rui]'s Articles
[Zhao, Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xiao, Wei-Lie]'s Articles
[Wang, Rui-Rui]'s Articles
[Zhao, Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 201112280006.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.