Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora
Xiao, Wei-Lie1; Wang, Rui-Rui2; Zhao, Wei1; Tian, Ren-Rong2; Shang, Shan-Zhai1; Yang, Liu-Meng2; Yang, Jian-Hong1; Pu, Jian-Xin1; Zheng, Yong-Tang2; Sun, Han-Dong1

This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 similar to 20.4 mu g/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.

KeywordSchisandra Rubriflora Lignan Nmr Cd Spectrum Anti-hiv-1 Activity
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
Indexed BySCI
WOS IDWOS:000278112400009
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
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GB/T 7714
Xiao, Wei-Lie,Wang, Rui-Rui,Zhao, Wei,et al. Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora[J]. ARCHIVES OF PHARMACAL RESEARCH,2010,33(5):697-701.
APA Xiao, Wei-Lie.,Wang, Rui-Rui.,Zhao, Wei.,Tian, Ren-Rong.,Shang, Shan-Zhai.,...&Sun, Han-Dong.(2010).Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora.ARCHIVES OF PHARMACAL RESEARCH,33(5),697-701.
MLA Xiao, Wei-Lie,et al."Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora".ARCHIVES OF PHARMACAL RESEARCH 33.5(2010):697-701.
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