Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora
Xiao, Wei-Lie1; Wang, Rui-Rui2; Zhao, Wei1; Tian, Ren-Rong2; Shang, Shan-Zhai1; Yang, Liu-Meng2; Yang, Jian-Hong1; Pu, Jian-Xin1; Zheng, Yong-Tang2; Sun, Han-Dong1
2010-05-01
发表期刊ARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
卷号33期号:5页码:697-701
摘要This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 similar to 20.4 mu g/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively.
关键词Schisandra Rubriflora Lignan Nmr Cd Spectrum Anti-hiv-1 Activity
资助信息NSFC [30830115, 20802082]; Chinese Academy of Sciences [KSCX1-YW-R-24, KSCX2-YW-R-185]; 973 Program [2009CB522300, 2009CB940900]; Yong Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]; Key Scientific and Technology Projects of China [2009ZX09501-029]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1007/s12272-010-0508-7
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000278112400009
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4176
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
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Xiao, Wei-Lie,Wang, Rui-Rui,Zhao, Wei,et al. Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora[J]. ARCHIVES OF PHARMACAL RESEARCH,2010,33(5):697-701.
APA Xiao, Wei-Lie.,Wang, Rui-Rui.,Zhao, Wei.,Tian, Ren-Rong.,Shang, Shan-Zhai.,...&Sun, Han-Dong.(2010).Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora.ARCHIVES OF PHARMACAL RESEARCH,33(5),697-701.
MLA Xiao, Wei-Lie,et al."Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora".ARCHIVES OF PHARMACAL RESEARCH 33.5(2010):697-701.
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