Antiproliferative activity of the main constituents from Phyllanthus emblica
Zhang, YJ; Nagao, T; Tanaka, T; Yang, CR; Okabe, H; Kouno, I
2004-02-01
发表期刊BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN0918-6158
卷号27期号:2页码:251-255
摘要Eighteen main compounds, including four norsesquiterpenoids (1-4) and 14 phenolic compounds (5-18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5-8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.
关键词Phyllanthus Emblica Euphorbiaceae Antiproliferative Activity Mk-1 Cell Hela Cell B16f10 Cell
学科领域Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000188653900025
引用统计
被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4160
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528521, Japan
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan
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Zhang, YJ,Nagao, T,Tanaka, T,et al. Antiproliferative activity of the main constituents from Phyllanthus emblica[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2004,27(2):251-255.
APA Zhang, YJ,Nagao, T,Tanaka, T,Yang, CR,Okabe, H,&Kouno, I.(2004).Antiproliferative activity of the main constituents from Phyllanthus emblica.BIOLOGICAL & PHARMACEUTICAL BULLETIN,27(2),251-255.
MLA Zhang, YJ,et al."Antiproliferative activity of the main constituents from Phyllanthus emblica".BIOLOGICAL & PHARMACEUTICAL BULLETIN 27.2(2004):251-255.
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