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题名: Antiproliferative activity of the main constituents from Phyllanthus emblica
作者: null(张颖君); Nagao, T; Tanaka, T; Yang, CR; Okabe, H; Kouno, I
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
关键词: Phyllanthus emblica ; Euphorbiaceae ; antiproliferative activity ; MK-1 cell ; HeLa cell ; B16F10 cell
英文摘要: Eighteen main compounds, including four norsesquiterpenoids (1-4) and 14 phenolic compounds (5-18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5-8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.
出版日期: 2004-02-01
卷号: 27, 期号:2, 页码:251-255
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy
ISSN号: 0918-6158
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4160
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Nagasaki Univ, Fac Pharmaceut Sci, Nagasaki 8528521, Japan
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
3.Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan

Recommended Citation:
Zhang, YJ; Nagao, T; Tanaka, T; Yang, CR; Okabe, H; Kouno, I.Antiproliferative activity of the main constituents from Phyllanthus emblica,BIOLOGICAL & PHARMACEUTICAL BULLETIN,2004,27(2):251-255
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