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New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity 期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 6, 页码: 1648-1666
作者:  Su,Lihua;  Zhang,Xintian;  Ma,Yunbao;  Geng,Changan;  Huang,Xiaoyan;  Hu,Jing;  Li,Tianze;  Tang,Shuang;  Shen,Cheng;  Gao,Zhen;  Zhang,Xuemei;  Chen,Ji-Jun
Adobe PDF(4074Kb)  |  收藏  |  浏览/下载：71/32  |  提交时间：2022/04/02
Guaianolide dimers  Artematrolides AeR  Artemisia atrovirens  Cytotoxicity  Cell cycle  Apoptosis  FARNESYL-PROTEIN TRANSFERASE  CELL-CYCLE ARREST  HEPATOCELLULAR-CARCINOMA  GUAIANOLIDES  LACTONES  INHIBITORS  ARTEMINOLIDE  APOPTOSIS  ARGYI  HELA  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：211/42  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Novel polyisoprenylated benzophenone derivatives from Garcinia paucinervis 期刊论文
TETRAHEDRON LETTERS, 2010, 卷号: 51, 期号: 18, 页码: 2442-2446
作者:  Gao, Xue-Mei;  Yu, Ting;  Lai, Fanny Shuk Fan;  Pu, Jian-Xin;  Qiao, Chun-Feng;  Zhou, Yan;  Liu, Xin;  Song, Jing-Zheng;  Luo, Kathy Qian;  Xu, Hong-Xi
Adobe PDF(433Kb)  |  收藏  |  浏览/下载：354/140  |  提交时间：2012/03/21
Garcinia Paucinervis  Benzophenone  Cytotoxiciry  Hela Cell  
A new amide from the leaves and twigs of Litsea auriculata 期刊论文
JOURNAL OF NATURAL MEDICINES, 2009, 卷号: 63, 期号: 3, 页码: 331-334
作者:  Tanaka, Hitoshi;  Yatsuhashi, Saya;  Yasuda, Tadashi;  Sato, Masaru;  Sakai, Eiji;  Xiao, Chen;  Murata, Hiroko;  Murata, Jin
Adobe PDF(240Kb)  |  收藏  |  浏览/下载：301/119  |  提交时间：2011/12/06
Litsea Auriculata  Lauraceae  Leaves  Twigs  Amides  Hela Cell  
Antiproliferative activity of the main constituents from Phyllanthus emblica 期刊论文
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2004, 卷号: 27, 期号: 2, 页码: 251-255
作者:  Zhang, YJ;  Nagao, T;  Tanaka, T;  Yang, CR;  Okabe, H;  Kouno, I
Adobe PDF(81Kb)  |  收藏  |  浏览/下载：182/44  |  提交时间：2012/03/21
Phyllanthus Emblica  Euphorbiaceae  Antiproliferative Activity  Mk-1 Cell  Hela Cell  B16f10 Cell