Chemical Constituents from the Leaves and Stems of Schisandra lancifolia
Xiao, Wei-Lie1; Yang, Liu-Meng2,3; Zhang, Hai-Bo1,4; Xue, Yong-Bo1,4; Yang, Guang-Yu1,5; Pu, Jian-Xin1; Wang, Rui-Rui2,3; Zheng, Yong-Tang2,3; Sun, Han-Dong1
2010-06-01
发表期刊CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN0009-2363
卷号58期号:6页码:852-855
摘要A new nortriterpenoid, 20-hydroxymicrandilactone D (1) and a novel lignan glycoside, lancilignanside A (2) were isolated from leaves and stems of Schisandra lancifolia, together with three known nortriterpenoids (3-5) and nine known phenolics (6-14). The structures of new compounds 1 and 2 were determined by detailed analysis of their 1D and 2D NMR spectra, and chemical evidences. In addition, compounds 1-2, 6-7, and 9-11 showed anti-human immunodeficiency virus (HIV)-1 activities with 50% effective concentration (EC50) in the range of 3.0-99.0 mu g/ml. Compound 12 was not bioactive in this assay with EC50 more than 200 mu g/ml.
关键词Nortriterpenoid Lignan Schisandra Lancifolia Anti-human Immunodeficiency Virus-1 Activity
资助信息NSFC [20802082, 30830115]; Chinese Academy of Sciences [KSCX1-YW-R-24]; Yong Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]; Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4124
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
3.Chinese Acad Sci, Lab Mol Immunopharmacol, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
5.Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 6501064, Yunnan, Peoples R China
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Xiao, Wei-Lie,Yang, Liu-Meng,Zhang, Hai-Bo,et al. Chemical Constituents from the Leaves and Stems of Schisandra lancifolia[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(6):852-855.
APA Xiao, Wei-Lie.,Yang, Liu-Meng.,Zhang, Hai-Bo.,Xue, Yong-Bo.,Yang, Guang-Yu.,...&Sun, Han-Dong.(2010).Chemical Constituents from the Leaves and Stems of Schisandra lancifolia.CHEMICAL & PHARMACEUTICAL BULLETIN,58(6),852-855.
MLA Xiao, Wei-Lie,et al."Chemical Constituents from the Leaves and Stems of Schisandra lancifolia".CHEMICAL & PHARMACEUTICAL BULLETIN 58.6(2010):852-855.
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