Polycyclic Polyprenylated Acylphloroglucinols and Chromone O-Glucosides from Hypericum henryi subsp uraloides
Chen, Xuan-Qin1,2; Li, Yan1; Cheng, Xiao1; Wang, Kou1,2; He, Juan1,2; Pan, Zheng-Hong1,2; Li, Ming-Ming1,2; Peng, Li-Yan1; Xu, Gang1; Zhao, Qin-Shi1
2010
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Volume7Issue:1Pages:196-204
AbstractTwo new C(30)-epimeric polycyclic polyprenylated acylphloroglucinols (PPAPs), named uralodins B and C (1 and 2, resp.), were isolated from the aerial parts of Hypericum henryi subsp. uraloides together with two new chromone glucosides. urachromones A and B (3 and 4, resp.), as well as 16 known compounds. Their structures were established by extensive NMR techniques and MS analysis. The epimers 1 and 2 always behaved like a single compound when examined by TLC, and were separated by HPLC. Their configuration was distinguished by comparative analysis of the NMR data with known analogues together with the ROESY experiment. All the isolated PPAPs were evaluated for their cytotoxic activities against HepG2, SGC7901, HL-60, and K562 cell lines. Compound 1 showed modest cytotoxic activities against SGC7901 and HL-60 cell lines, and 2 showed modest cytotoxic activities against HepG2, SGC7901, HL-60, and K562 cell lines.
Keyword2 Polyisoprenylated Benzophenones St Johns Wort Natural-products Cuban Propolis Derivatives Xanthones Hyperforin Glycosides Japonicum Assays
Subject AreaBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000274264000013
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4054
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xuan-Qin,Li, Yan,Cheng, Xiao,et al. Polycyclic Polyprenylated Acylphloroglucinols and Chromone O-Glucosides from Hypericum henryi subsp uraloides[J]. CHEMISTRY & BIODIVERSITY,2010,7(1):196-204.
APA Chen, Xuan-Qin.,Li, Yan.,Cheng, Xiao.,Wang, Kou.,He, Juan.,...&Zhao, Qin-Shi.(2010).Polycyclic Polyprenylated Acylphloroglucinols and Chromone O-Glucosides from Hypericum henryi subsp uraloides.CHEMISTRY & BIODIVERSITY,7(1),196-204.
MLA Chen, Xuan-Qin,et al."Polycyclic Polyprenylated Acylphloroglucinols and Chromone O-Glucosides from Hypericum henryi subsp uraloides".CHEMISTRY & BIODIVERSITY 7.1(2010):196-204.
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