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题名: Synthesis of analogues of flazin, in particular, flazinamide, as promising Anti-HIV agents
作者: Tang, Jian-Guo2, 3; Wang, Yun-Hua1, 3; Wang, Rui-Rui1, 3; Dong, Ze-Jun2; Yang, Liu-Meng1; Zheng, Yong-Tang1; Liu, Ji-Kai2
刊名: CHEMISTRY & BIODIVERSITY
关键词: cyclohexapeptide ; annomuricatin A
英文摘要: Flazin isolated from the fruiting bodies of Suillus granulatus was found to possess weak anti-HIV activity (EC50=2.36 mu m, TI= 12.1). To establish a SAR study, 46 flazin analogues were synthesized, and their anti-HIV activities were evaluated in vitro. Among them, flazinamide (9a) showed the most potent activity with an EC50 value of 0.38 pm and a TI value of 312.0. The results suggested that appropriate substituents at positions 3, 1', and 5' of flazin might play a crucial role in determining their anti-HIV activities, and that flazinamide can be considered as a promising, readily available anti-HIV agent.
出版日期: 2008
卷号: 5, 期号:3, 页码:447-460
语种: 英语
收录类别: SCI
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/4016
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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10.1002@cbdv.200890044.pdf(243KB)期刊论文出版稿开放获取View Download

作者单位: 1.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Phytochem & Plant Resources W China, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Tang, Jian-Guo,Wang, Yun-Hua,Wang, Rui-Rui,et al. Synthesis of analogues of flazin, in particular, flazinamide, as promising Anti-HIV agents[J]. CHEMISTRY & BIODIVERSITY,2008,5(3):447-460.
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文件名: 10.1002@cbdv.200890044.pdf
格式: Adobe PDF
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