Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum
Zhang, Ling1,4; Luo, Rong-Hua2,3; Wang, Fei1; Jiang, Meng-Yuan1,4; Dong, Ze-Jun1; Yang, Liu-Meng2,3; Zheng, Yong-Tang2,3; Liu, Ji-Kai1
2010
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号12期号:1页码:152-155
摘要Trigonothyrins A-C (1-3), which are highly functionalized daphnane diterpenoids, were isolated from the stems of Trigonostemon thyrsoideum. Compounds 1-3 represent the first examples of daphnanes with an oxygen-bridged four-membered-ring system, and a linkage mode of 12,13,14-orthoester. Compound 3 was observed to inhibit HIV-1 induced cytopathic effects. The EC(50) value was 2.19 mu g/mL, and the therapeutic index (TI) was more than 90.
资助信息National Basic Research Program of China [2009CB522300]; National Natural Science Foundation of China [30830113]
学科领域Chemistry, Organic
DOI10.1021/ol9025638
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000272937200039
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/4012
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Zhang, Ling,Luo, Rong-Hua,Wang, Fei,et al. Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum[J]. ORGANIC LETTERS,2010,12(1):152-155.
APA Zhang, Ling.,Luo, Rong-Hua.,Wang, Fei.,Jiang, Meng-Yuan.,Dong, Ze-Jun.,...&Liu, Ji-Kai.(2010).Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum.ORGANIC LETTERS,12(1),152-155.
MLA Zhang, Ling,et al."Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum".ORGANIC LETTERS 12.1(2010):152-155.
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