Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum
Zhang, Ling1,4; Luo, Rong-Hua2,3; Wang, Fei1; Jiang, Meng-Yuan1,4; Dong, Ze-Jun1; Yang, Liu-Meng2,3; Zheng, Yong-Tang2,3; Liu, Ji-Kai1
2010
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume12Issue:1Pages:152-155
AbstractTrigonothyrins A-C (1-3), which are highly functionalized daphnane diterpenoids, were isolated from the stems of Trigonostemon thyrsoideum. Compounds 1-3 represent the first examples of daphnanes with an oxygen-bridged four-membered-ring system, and a linkage mode of 12,13,14-orthoester. Compound 3 was observed to inhibit HIV-1 induced cytopathic effects. The EC(50) value was 2.19 mu g/mL, and the therapeutic index (TI) was more than 90.
Subject AreaChemistry, Organic
DOI10.1021/ol9025638
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000272937200039
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/4012
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ling,Luo, Rong-Hua,Wang, Fei,et al. Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum[J]. ORGANIC LETTERS,2010,12(1):152-155.
APA Zhang, Ling.,Luo, Rong-Hua.,Wang, Fei.,Jiang, Meng-Yuan.,Dong, Ze-Jun.,...&Liu, Ji-Kai.(2010).Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum.ORGANIC LETTERS,12(1),152-155.
MLA Zhang, Ling,et al."Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum".ORGANIC LETTERS 12.1(2010):152-155.
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