Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum

doi:10.1021/ol9025638

	Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum
	Zhang, Ling 1,4; Luo, Rong-Hua 2,3; Wang, Fei 1; Jiang, Meng-Yuan 1,4; Dong, Ze-Jun1 ; Yang, Liu-Meng 2,3; Zheng, Yong-Tang 2,3; Liu, Ji-Kai 1
	2010
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	12 期号:1 页码:152-155
摘要	Trigonothyrins A-C (1-3), which are highly functionalized daphnane diterpenoids, were isolated from the stems of Trigonostemon thyrsoideum. Compounds 1-3 represent the first examples of daphnanes with an oxygen-bridged four-membered-ring system, and a linkage mode of 12,13,14-orthoester. Compound 3 was observed to inhibit HIV-1 induced cytopathic effects. The EC(50) value was 2.19 mu g/mL, and the therapeutic index (TI) was more than 90.
学科领域	Chemistry, Organic
DOI	10.1021/ol9025638
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000272937200039
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/4012
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ling,Luo, Rong-Hua,Wang, Fei,et al. Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum[J]. ORGANIC LETTERS,2010,12(1):152-155.
APA	Zhang, Ling.,Luo, Rong-Hua.,Wang, Fei.,Jiang, Meng-Yuan.,Dong, Ze-Jun.,...&Liu, Ji-Kai.(2010).Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum.ORGANIC LETTERS,12(1),152-155.
MLA	Zhang, Ling,et al."Highly Functionalized Daphnane Diterpenoids from Trigonostemon thyrsoideum".ORGANIC LETTERS 12.1(2010):152-155.

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