Hypophyllins A-D, Labdane-Type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya "Rosea"

doi:10.1021/acs.orglett.6b03388

	Hypophyllins A-D, Labdane-Type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya "Rosea"
	Wu, Xing-De; Luo, Dan; Tu, Wen-Chao; Deng, Zhen-Tao; Chen, Xue-Jiao; Su, Jia; Ji, Xu; Zhao, Qin-Shi
	2016-12-16
Source Publication	ORGANIC LETTERS
Volume	18 Issue:24 Pages:6484-6487
Abstract	Three rearranged labdane-type diterpenoids, hypophyllins A-C (1-3), and a caged labdane diterpenoid possessing a 8,9-dioxatricyclic[4.2.1.1(3,7)]decane moiety, hypophyllin D (4), as well as two new biogenetically related diterpernoids, hypophyllins E (5) and F (6), were isolated from the aerial parts of Hypoestes phyllostachya "Rosea". The absolute configurations of 1-4 were determined by X-ray diffraction analysis. The plausible biogenetic pathway for 1-4 was also proposed. Compounds 4 and 5 showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.
DOI	10.1021/acs.orglett.6b03388
Indexed By	SCI
Language	英语
WOS ID	WOS:000390180300068
Citation statistics	Cited Times:16[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/33787
Collection	植物化学与西部植物资源持续利用国家重点实验室
Affiliation	Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
Recommended Citation GB/T 7714	Wu, Xing-De,Luo, Dan,Tu, Wen-Chao,et al. Hypophyllins A-D, Labdane-Type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya "Rosea"[J]. ORGANIC LETTERS,2016,18(24):6484-6487.
APA	Wu, Xing-De.,Luo, Dan.,Tu, Wen-Chao.,Deng, Zhen-Tao.,Chen, Xue-Jiao.,...&Zhao, Qin-Shi.(2016).Hypophyllins A-D, Labdane-Type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya "Rosea".ORGANIC LETTERS,18(24),6484-6487.
MLA	Wu, Xing-De,et al."Hypophyllins A-D, Labdane-Type Diterpenoids with Vasorelaxant Activity from Hypoestes phyllostachya "Rosea"".ORGANIC LETTERS 18.24(2016):6484-6487.

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