Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi
Liu, Yu-Chen1,2; Su, Jia1; Wu, Xing-De1; Zhang, Zhi-Jun1,2; Fan, Min1,2; Zhu, Qin-Feng1,2; He, Juan1; Li, Xiao-Nian1; Peng, Li-Yan1; Cheng, Xiao1; Zhao, Qin-Shi1
2016-12-01
Source PublicationFITOTERAPIA
Volume115Issue:1Pages:148-154
AbstractA series of new Lycopodium alkaloids, namely 1-epi-malycorin A (1), 1-epi-17S-hydroxymalycorin A (2), 6 alpha-thydroxyphlegmariurine A (3), 2S,4R-dihydroxyfawcettimine (4), and 16-hydroxylycodine (5), together with 24 known ones, have been isolated from the club moss Phlegmariurus henryi. The structures of the new compounds were determined by extensive spectroscopic analysis, including 1D and 2D NMR, as well as X-ray crystallographic analysis. Among them, the absolute configurations of 1, 2, and 4 and the structure of 3 were confirmed on the basis of the single-crystal X-ray diffraction analysis. 1-Epi-17S-hydroxymalycorin A (2) was a unique C19N-type Lycopodium alkaloid consisting of a serratinine skeleton with 1,2-propanediol unit. 2S,4R-dihydroxyfawcettimine (4) was a 2,4-dihydroxy derivative of fawcettimine.16-Hydroxylycodine (5) was the oxidative product of lycodine with an unusual hydroxymethyl group at C-15. All new compounds were evaluated for in vitro acetylcholinesterase (AChE) inhibitory activity and cytotoxicity against four human cancer cell lines. (C) 2016 Elsevier B.V. All rights reserved.
KeywordPhlegmariurus Henryi Lycopodium Alkaloids Anti-ache Activity Cytotoxicity
DOI10.1016/j.fitote.2016.10.005
Indexed BySCI
Language英语
WOS IDWOS:000389113300024
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33756
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yu-Chen,Su, Jia,Wu, Xing-De,et al. Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi[J]. FITOTERAPIA,2016,115(1):148-154.
APA Liu, Yu-Chen.,Su, Jia.,Wu, Xing-De.,Zhang, Zhi-Jun.,Fan, Min.,...&Zhao, Qin-Shi.(2016).Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi.FITOTERAPIA,115(1),148-154.
MLA Liu, Yu-Chen,et al."Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi".FITOTERAPIA 115.1(2016):148-154.
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