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题名: Spirostanol glycosides with hemostatic and antimicrobial activities from Trillium kamtschaticum
作者: Chen, Yu1, 2, 4; Ni, Wei1, 4; Yan, Huan1, 4; Qin, Xu-Jie1, 4; Khan, Afsar1, 3; Liu, Hui1, 2, 4; Shu, Tong1, 2, 4; Jin, Ling-Yu1, 4; null(刘海洋)1, 4
刊名: PHYTOCHEMISTRY
关键词: Trillium kamtschaticum ; Trilliaceae ; Spirostanol glycosides ; Hemostatic activity ; Antimicrobial activity
英文摘要: Ten spirostanol glycosides, trillikamtosides A-J, together with eleven known analogues, were isolated from the hemostatic fraction of the 75% aqueous EtOH extract of the whole herbs of Trillium kamtschaticum. Their structures were established by extensive spectroscopic data analysis and chemical methods. The aglycones of three of these compounds had unique 3 beta,17 alpha-dihydroxy-spirostanes featuring a double bond between C-4 and C-5, while two others represent a rare class of spirostanol glycosides which possess a 5(6 -> 7) abeo-steroidal aglycone. All the compounds were evaluated for their hemostatic and antimicrobial activities. Three of the spirostanol glycosides exhibited induced-platelet aggregation at a concentration of 300 mu g/mL with maximal induced-platelet aggregation rates of 72%, 71%, and 62% in rabbits, respectively, and their EC50 values were 492.7, 203.3, and 109.8 mu M. Five of the spirostanol glycosides showed an anti-Candida albicans effect with MIC values of 21.1,10.6, 8.8, 21.6, and 11.0 mu M, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
出版日期: 2016-11-01
卷号: 131, 页码:165-173
DOI标识: 10.1016/j.phytochem.2016.09.006
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/33642
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan
4.Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China

Recommended Citation:
Chen, Yu,Ni, Wei,Yan, Huan,et al. Spirostanol glycosides with hemostatic and antimicrobial activities from Trillium kamtschaticum[J]. PHYTOCHEMISTRY,2016,131:165-173.
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