Spirostanol glycosides with hemostatic and antimicrobial activities from Trillium kamtschaticum
Chen, Yu1,2,4; Ni, Wei1,4; Yan, Huan1,4; Qin, Xu-Jie1,4; Khan, Afsar1,3; Liu, Hui1,2,4; Shu, Tong1,2,4; Jin, Ling-Yu1,4; Liu, Hai-Yang1,4
2016-11-01
发表期刊PHYTOCHEMISTRY
卷号131页码:165-173
摘要Ten spirostanol glycosides, trillikamtosides A-J, together with eleven known analogues, were isolated from the hemostatic fraction of the 75% aqueous EtOH extract of the whole herbs of Trillium kamtschaticum. Their structures were established by extensive spectroscopic data analysis and chemical methods. The aglycones of three of these compounds had unique 3 beta,17 alpha-dihydroxy-spirostanes featuring a double bond between C-4 and C-5, while two others represent a rare class of spirostanol glycosides which possess a 5(6 -> 7) abeo-steroidal aglycone. All the compounds were evaluated for their hemostatic and antimicrobial activities. Three of the spirostanol glycosides exhibited induced-platelet aggregation at a concentration of 300 mu g/mL with maximal induced-platelet aggregation rates of 72%, 71%, and 62% in rabbits, respectively, and their EC50 values were 492.7, 203.3, and 109.8 mu M. Five of the spirostanol glycosides showed an anti-Candida albicans effect with MIC values of 21.1,10.6, 8.8, 21.6, and 11.0 mu M, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Trillium Kamtschaticum Trilliaceae Spirostanol Glycosides Hemostatic Activity Antimicrobial Activity
资助信息National Natural Science Funding of China(31600283; Natural Science Foundation of Yunnan Province(2015FA031); 31570363)
DOI10.1016/j.phytochem.2016.09.006
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000385692000019
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/33642
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan
4.Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
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GB/T 7714
Chen, Yu,Ni, Wei,Yan, Huan,et al. Spirostanol glycosides with hemostatic and antimicrobial activities from Trillium kamtschaticum[J]. PHYTOCHEMISTRY,2016,131:165-173.
APA Chen, Yu.,Ni, Wei.,Yan, Huan.,Qin, Xu-Jie.,Khan, Afsar.,...&Liu, Hai-Yang.(2016).Spirostanol glycosides with hemostatic and antimicrobial activities from Trillium kamtschaticum.PHYTOCHEMISTRY,131,165-173.
MLA Chen, Yu,et al."Spirostanol glycosides with hemostatic and antimicrobial activities from Trillium kamtschaticum".PHYTOCHEMISTRY 131(2016):165-173.
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