Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus
Cheng, Gui-Guang1,2,3; Li, Dan1,3; Hou, Bo1,3; Li, Xiao-Nian1,3; Liu, Lu1,3; Chen, Ying-Ying1,3; Lunga, Paul-Keilah1,3; Khan, Afsar1,3,4; Liu, Ya-Ping1,3; Zuo, Zhi-Li1,3; Luo, Xiao-Dong1,3
2016-09-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume79Issue:9Pages:2158-2166
AbstractThe new melokhanines A-J (1-10) and 22 known (11-32) alkaloids were isolated from the twigs and leaves of Melodinus khasianus. The new compounds and their absolute configurations were elucidated by extensive analysis of spectroscopic, X-ray diffraction, and computational data. Melokhanine A (1), composed of a hydroxyindolinone linked to an octahydrofuro[2,3-b]pyridine moiety, is an unprecedented monoterpenoid indole alkaloid. Melokhanines B-H (2-8) possess a new 6/5/5/6/6 pentacyclic indole alkaloid skeleton. Alkaloids 1-16, 25-27, 31, and 32 showed the best antibacterial activity against Pseudomonas aeruginosa (MIC range 2-22 mu M). Among the seven dermatophytes tested, compound 1 showed significant inhibitory activity against Microsporum canis, M. ferrugineum, and Trichophyton ajelloi (MIC range 38-150 mu M), i.e., half the efficacy of the positive control, griseofulvin.
DOI10.1021/acs.jnatprod.6b00011
Indexed BySCI
Language英语
WOS IDWOS:000384156700002
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/33641
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 650500, Peoples R China
3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
4.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan
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GB/T 7714
Cheng, Gui-Guang,Li, Dan,Hou, Bo,et al. Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(9):2158-2166.
APA Cheng, Gui-Guang.,Li, Dan.,Hou, Bo.,Li, Xiao-Nian.,Liu, Lu.,...&Luo, Xiao-Dong.(2016).Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus.JOURNAL OF NATURAL PRODUCTS,79(9),2158-2166.
MLA Cheng, Gui-Guang,et al."Melokhanines A-J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus".JOURNAL OF NATURAL PRODUCTS 79.9(2016):2158-2166.
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