| Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi | |
Liu, Ya-Ping1,5; Yue, Grace Gar-Lee2,3; Lee, Julia Kin-Ming2,3; Feng, Tao4; Zhao, Yun-Li1,5; Li, Yan1,5 ; Lau, Clara Bik-San2,3; Luo, Xiao-Dong1,5
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| 2016-10-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 卷号 | 26期号:20页码:4895-4898 |
| 摘要 | Melodinine V (1) with a vincanol-eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells. (C) 2016 Elsevier Ltd. All rights reserved. |
| 关键词 | Melodinine v Bisindole Inhibited Cell Proliferation Cell Cycle Arrest Cellular Apoptosis Ht-29 Cells |
| DOI | 10.1016/j.bmcl.2016.09.023 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000385498500008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33628 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China 4.South Cent Univ Nationalities, Coll Pharmaceut Sci, Wuhan, Peoples R China 5.Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ya-Ping,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,et al. Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(20):4895-4898. |
| APA | Liu, Ya-Ping.,Yue, Grace Gar-Lee.,Lee, Julia Kin-Ming.,Feng, Tao.,Zhao, Yun-Li.,...&Luo, Xiao-Dong.(2016).Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(20),4895-4898. |
| MLA | Liu, Ya-Ping,et al."Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.20(2016):4895-4898. |
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