Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation
Liu, Qiuyan2,3; Shu, Xiaoli4; Sun, Anna4; Sun, Qiaoling4; Zhang, Chaoxiong2,3; An, Huazhang2,3; Liu, Jikai1; Cao, Xuetao2,3,4
Corresponding Authorjkl@public.km.yn.cn ; caoxt@public3.sta.net.cn
2008-08-01
Source PublicationINTERNATIONAL IMMUNOPHARMACOLOGY
ISSN1567-5769
Volume8Issue:8Pages:1103-1111
AbstractDendritic cells (DCs) play crucial roles in Linking innate immunity and adaptive immunity, thus being regarded as one of the important targets of immunosuppressant. Natural small molecule products isolated from plants, such as fungal metabolites, have been shown to be effective in the treatment of cancer, inflammation and autoimmune diseases. Albaconol is a new kind of prenylated resorcinols isolated from the fruiting bodies of the inedible mushroom Albatrellus confluens, and has been shown to inhibit tumor cell growth. Considering that most of small molecule compounds with antitumor activity always exert immunosuppressive effect, so we wonder whether albaconol could inhibit maturation and antigen presentation of DCs, thus acting as immunosuppressant. Here we demonstrate that albaconol significantly inhibits LPS-induced production of proinflammatory cytokines TNF-alpha, IL-6, IL-1beta, and expression of MHC-II and co-stimulatory molecules by DCs. Furthermore, albaconol markedly inhibits T cell-stimulating capacity of DCs and DCs-initiated antigen-specific T cell response, indicating albaconol can inhibit phenotypic and functional maturation of DCs. Inhibition of LPS-induced NF-kappa B activation may contribute to the above immunosuppressive or anti-inflammatory activities of albaconol. Therefore, our results suggest that natural small molecule albaconol may be a potential immunosuppressive and anti-inflammatory agent through suppressing DCs function via impairment of NF-kappa B activation. (C) 2008 Elsevier B.V. All rights reserved.
KeywordDendritic Cell Immunosuppression Inflammation Cytokines Nf-kappa b
Subject AreaImmunology ; Pharmacology & Pharmacy
DOI10.1016/j.intimp.2008.04.001
Indexed BySCI
Language英语
WOS Research AreaImmunology ; Pharmacology & Pharmacy
WOS SubjectImmunology ; Pharmacology & Pharmacy
WOS IDWOS:000257577000006
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/2921
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Natl Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China
3.Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China
4.Zhejiang Univ, Sch Med, Inst Immunol, Hangzhou 310058, Zhejiang, Peoples R China
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Liu, Qiuyan,Shu, Xiaoli,Sun, Anna,et al. Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2008,8(8):1103-1111.
APA Liu, Qiuyan.,Shu, Xiaoli.,Sun, Anna.,Sun, Qiaoling.,Zhang, Chaoxiong.,...&Cao, Xuetao.(2008).Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation.INTERNATIONAL IMMUNOPHARMACOLOGY,8(8),1103-1111.
MLA Liu, Qiuyan,et al."Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation".INTERNATIONAL IMMUNOPHARMACOLOGY 8.8(2008):1103-1111.
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