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题名: Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation
作者: Liu, Qiuyan2, 3; Shu, Xiaoli4; Sun, Anna4; Sun, Qiaoling4; Zhang, Chaoxiong2, 3; An, Huazhang2, 3; Liu, Jikai1; Cao, Xuetao2, 3, 4
刊名: INTERNATIONAL IMMUNOPHARMACOLOGY
关键词: dendritic cell ; immunosuppression ; inflammation ; cytokines ; NF-kappa B
英文摘要: Dendritic cells (DCs) play crucial roles in Linking innate immunity and adaptive immunity, thus being regarded as one of the important targets of immunosuppressant. Natural small molecule products isolated from plants, such as fungal metabolites, have been shown to be effective in the treatment of cancer, inflammation and autoimmune diseases. Albaconol is a new kind of prenylated resorcinols isolated from the fruiting bodies of the inedible mushroom Albatrellus confluens, and has been shown to inhibit tumor cell growth. Considering that most of small molecule compounds with antitumor activity always exert immunosuppressive effect, so we wonder whether albaconol could inhibit maturation and antigen presentation of DCs, thus acting as immunosuppressant. Here we demonstrate that albaconol significantly inhibits LPS-induced production of proinflammatory cytokines TNF-alpha, IL-6, IL-1beta, and expression of MHC-II and co-stimulatory molecules by DCs. Furthermore, albaconol markedly inhibits T cell-stimulating capacity of DCs and DCs-initiated antigen-specific T cell response, indicating albaconol can inhibit phenotypic and functional maturation of DCs. Inhibition of LPS-induced NF-kappa B activation may contribute to the above immunosuppressive or anti-inflammatory activities of albaconol. Therefore, our results suggest that natural small molecule albaconol may be a potential immunosuppressive and anti-inflammatory agent through suppressing DCs function via impairment of NF-kappa B activation. (C) 2008 Elsevier B.V. All rights reserved.
出版日期: 2008-08-01
卷号: 8, 期号:8, 页码:1103-1111
DOI标识: 10.1016/j.intimp.2008.04.001
语种: 英语
收录类别: SCI
学科分类: Immunology; Pharmacology & Pharmacy
ISSN号: 1567-5769
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2921
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Natl Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China
3.Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China
4.Zhejiang Univ, Sch Med, Inst Immunol, Hangzhou 310058, Zhejiang, Peoples R China

Recommended Citation:
Liu, QY; Shu, XL; Sun, A; Sun, QL; Zhang, CX; An, HZ; Liu, JK; Cao, XT.Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappa B activation,INTERNATIONAL IMMUNOPHARMACOLOGY,2008,8(8):1103-1111
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