Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica
Li, Jun-Zhu1; Qing, Chen2; Chen, Chang-Xiang1; Hao, Xiao-Jiang1; Liu, Hai-Yang1
2009-04-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号19期号:7页码:1956-1959
摘要A new cardenolide, 12 beta, 14 beta-dihydroxy-3 beta, 19-epoxy-3 alpha-methoxy-5 alpha-card-20(22)-enolide (6), and a new doubly linked cardenolide glycoside, 12 beta-hydroxycalotropin (13), together with eleven known compounds, coroglaucigenin (1), 12 beta-hydroxycoroglaucigenin (2), calotropagenin (3), desglucouzarin (4), 6'-O-feruloyl-desglucouzarin (5), calotropin (7), uscharidin (8), asclepin (9), 16 alpha-hydroxyasclepin (10), 16 alpha-acetoxycalotropin (11), and 16 alpha-acetoxyasclepin (12), were isolated from the aerial part of ornamental milkweed, Asclepias curassavica and chemically elucidated through spectral analyses. All the isolates were evaluated for their cytotoxic activity against HepG2 and Raji cell lines. The results showed that asclepin (9) had the strongest cytotoxic activity with an IC(50) value of 0.02 mu M against the two cancer cell lines and the new compound 13 had significant cytotoxic activity with IC(50) values of 0.69 and 1.46 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
关键词Asclepias Curassavica Asclepiadaceae Cardenolide Cardenolide Glycoside Cytotoxicity
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2009.02.045
收录类别SCI
语种英语
WOS记录号WOS:000264169700025
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2901
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China
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GB/T 7714
Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,et al. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(7):1956-1959.
APA Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,Hao, Xiao-Jiang,&Liu, Hai-Yang.(2009).Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(7),1956-1959.
MLA Li, Jun-Zhu,et al."Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.7(2009):1956-1959.
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