Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica

doi:10.1016/j.bmcl.2009.02.045

	Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica
	Li, Jun-Zhu 1; Qing, Chen 2; Chen, Chang-Xiang1 ; Hao, Xiao-Jiang1 ; Liu, Hai-Yang1
	2009-04-01
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
卷号	19 期号:7 页码:1956-1959
摘要	A new cardenolide, 12 beta, 14 beta-dihydroxy-3 beta, 19-epoxy-3 alpha-methoxy-5 alpha-card-20(22)-enolide (6), and a new doubly linked cardenolide glycoside, 12 beta-hydroxycalotropin (13), together with eleven known compounds, coroglaucigenin (1), 12 beta-hydroxycoroglaucigenin (2), calotropagenin (3), desglucouzarin (4), 6'-O-feruloyl-desglucouzarin (5), calotropin (7), uscharidin (8), asclepin (9), 16 alpha-hydroxyasclepin (10), 16 alpha-acetoxycalotropin (11), and 16 alpha-acetoxyasclepin (12), were isolated from the aerial part of ornamental milkweed, Asclepias curassavica and chemically elucidated through spectral analyses. All the isolates were evaluated for their cytotoxic activity against HepG2 and Raji cell lines. The results showed that asclepin (9) had the strongest cytotoxic activity with an IC(50) value of 0.02 mu M against the two cancer cell lines and the new compound 13 had significant cytotoxic activity with IC(50) values of 0.69 and 1.46 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
关键词	Asclepias Curassavica Asclepiadaceae Cardenolide Cardenolide Glycoside Cytotoxicity
学科领域	Chemistry, Medicinal ; Chemistry, Organic
DOI	10.1016/j.bmcl.2009.02.045
收录类别	SCI
语种	英语
WOS记录号	WOS:000264169700025
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2901
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China
推荐引用方式 GB/T 7714	Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,et al. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(7):1956-1959.
APA	Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,Hao, Xiao-Jiang,&Liu, Hai-Yang.(2009).Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(7),1956-1959.
MLA	Li, Jun-Zhu,et al."Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.7(2009):1956-1959.

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