Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica
Li, Jun-Zhu1; Qing, Chen2; Chen, Chang-Xiang1; Hao, Xiao-Jiang1; Liu, Hai-Yang1
AbstractA new cardenolide, 12 beta, 14 beta-dihydroxy-3 beta, 19-epoxy-3 alpha-methoxy-5 alpha-card-20(22)-enolide (6), and a new doubly linked cardenolide glycoside, 12 beta-hydroxycalotropin (13), together with eleven known compounds, coroglaucigenin (1), 12 beta-hydroxycoroglaucigenin (2), calotropagenin (3), desglucouzarin (4), 6'-O-feruloyl-desglucouzarin (5), calotropin (7), uscharidin (8), asclepin (9), 16 alpha-hydroxyasclepin (10), 16 alpha-acetoxycalotropin (11), and 16 alpha-acetoxyasclepin (12), were isolated from the aerial part of ornamental milkweed, Asclepias curassavica and chemically elucidated through spectral analyses. All the isolates were evaluated for their cytotoxic activity against HepG2 and Raji cell lines. The results showed that asclepin (9) had the strongest cytotoxic activity with an IC(50) value of 0.02 mu M against the two cancer cell lines and the new compound 13 had significant cytotoxic activity with IC(50) values of 0.69 and 1.46 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
KeywordAsclepias Curassavica Asclepiadaceae Cardenolide Cardenolide Glycoside Cytotoxicity
Subject AreaChemistry, Medicinal ; Chemistry, Organic
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000264169700025
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Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China
Recommended Citation
GB/T 7714
Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,et al. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(7):1956-1959.
APA Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,Hao, Xiao-Jiang,&Liu, Hai-Yang.(2009).Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(7),1956-1959.
MLA Li, Jun-Zhu,et al."Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.7(2009):1956-1959.
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