Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica
Li, Jun-Zhu1; Qing, Chen2; Chen, Chang-Xiang1; Hao, Xiao-Jiang1; Liu, Hai-Yang1
2009-04-01
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume19Issue:7Pages:1956-1959
AbstractA new cardenolide, 12 beta, 14 beta-dihydroxy-3 beta, 19-epoxy-3 alpha-methoxy-5 alpha-card-20(22)-enolide (6), and a new doubly linked cardenolide glycoside, 12 beta-hydroxycalotropin (13), together with eleven known compounds, coroglaucigenin (1), 12 beta-hydroxycoroglaucigenin (2), calotropagenin (3), desglucouzarin (4), 6'-O-feruloyl-desglucouzarin (5), calotropin (7), uscharidin (8), asclepin (9), 16 alpha-hydroxyasclepin (10), 16 alpha-acetoxycalotropin (11), and 16 alpha-acetoxyasclepin (12), were isolated from the aerial part of ornamental milkweed, Asclepias curassavica and chemically elucidated through spectral analyses. All the isolates were evaluated for their cytotoxic activity against HepG2 and Raji cell lines. The results showed that asclepin (9) had the strongest cytotoxic activity with an IC(50) value of 0.02 mu M against the two cancer cell lines and the new compound 13 had significant cytotoxic activity with IC(50) values of 0.69 and 1.46 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
KeywordAsclepias Curassavica Asclepiadaceae Cardenolide Cardenolide Glycoside Cytotoxicity
Subject AreaChemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2009.02.045
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000264169700025
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/2901
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China
Recommended Citation
GB/T 7714
Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,et al. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(7):1956-1959.
APA Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,Hao, Xiao-Jiang,&Liu, Hai-Yang.(2009).Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(7),1956-1959.
MLA Li, Jun-Zhu,et al."Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.7(2009):1956-1959.
Files in This Item: Download All
File Name/Size DocType Version Access License
201110260038.pdf(320KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Jun-Zhu]'s Articles
[Qing, Chen]'s Articles
[Chen, Chang-Xiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Jun-Zhu]'s Articles
[Qing, Chen]'s Articles
[Chen, Chang-Xiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Jun-Zhu]'s Articles
[Qing, Chen]'s Articles
[Chen, Chang-Xiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 201110260038.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.