| A Drug for Treating Cardio-Cerebrovascular Diseases-Phenolic Compds of Erigeron breviscapus |
| Sun Handong ; Zhao Qinshi
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| 2009
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| 发表期刊 | PROGRESS IN CHEMISTRY
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| ISSN | 1005-281X
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| 卷号 | 21期号:1页码:77-83 |
| 摘要 | Erigeron breviscapus (Vant.) Hand.-Mazz. (compositae) is a well known drug as traditional Chinese medicine. The whole herb is used to treat a variety of paralysis and its sequelae originated from apoplexy and atherothrombotic of brain. Two kinds of drugs (injection liquid and tablets) developed from this medicine have been used in clinic for the cerebral embolism, cerebral thrombosis, paralysis arisen from cerebral embolism, coronary heart disease, angina pectoris, acute rend function failure, and nephritic syndrome etc., since 1980s. It has been collected in "Pharmacopoeia of P. R. China (2005)". Our research group have reinvestigated and recognized the chemical and bioactive constituents from E. breviscapus since 1992. As the results, we found a series of phenolic compds, such as 1,5-, 3, 5- and 4, 5-dicarffeoylquinic esters, and erigoster A and B, which also possessed same bioactivities with sculellarin isolated and identified by Guan and Zhang([4.5]) in 1980s. Based on the above investigation, the new drug "Injection of Dengzhanxixin Phenols" developed by our research team has completed phase III clinical trial in June 2007. The production certificate is in application. This new drug, with clear bioactive ingredient composition, well-controlled quality, solid therapeutic effect, and complete intellectual property, is believed as new generation drug in the treatment of brain and heart vas related diseases. |
| 关键词 | Traditional Chinese Medicine
Erigeron Breviscapus (Compositae)
Cardio-cerebrovascular Diseases
Components
Dengzhanxixin Phenols
NE. TypE.PrE.aration Of E. brE.iscapus
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| 学科领域 | Chemistry, Multidisciplinary
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| 收录类别 | SCI
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| 语种 | 英语
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| WOS记录号 | WOS:000262685700009
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kib.ac.cn/handle/151853/2875
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| 专题 | 植物化学与西部植物资源持续利用国家重点实验室
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| 作者单位 | Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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推荐引用方式
GB/T 7714 |
Sun Handong,Zhao Qinshi. A Drug for Treating Cardio-Cerebrovascular Diseases-Phenolic Compds of Erigeron breviscapus[J]. PROGRESS IN CHEMISTRY,2009,21(1):77-83.
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| APA |
Sun Handong,&Zhao Qinshi.(2009).A Drug for Treating Cardio-Cerebrovascular Diseases-Phenolic Compds of Erigeron breviscapus.PROGRESS IN CHEMISTRY,21(1),77-83.
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| MLA |
Sun Handong,et al."A Drug for Treating Cardio-Cerebrovascular Diseases-Phenolic Compds of Erigeron breviscapus".PROGRESS IN CHEMISTRY 21.1(2009):77-83.
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