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题名: A Drug for Treating Cardio-Cerebrovascular Diseases-Phenolic Compds of Erigeron breviscapus
作者: null(孙汉董)1; null(赵勤实)1
刊名: PROGRESS IN CHEMISTRY
关键词: traditional Chinese medicine ; Erigeron breviscapus (compositae) ; cardio-cerebrovascular diseases ; components ; Dengzhanxixin phenols ; new type preparation of E. breviscapus
英文摘要: Erigeron breviscapus (Vant.) Hand.-Mazz. (compositae) is a well known drug as traditional Chinese medicine. The whole herb is used to treat a variety of paralysis and its sequelae originated from apoplexy and atherothrombotic of brain. Two kinds of drugs (injection liquid and tablets) developed from this medicine have been used in clinic for the cerebral embolism, cerebral thrombosis, paralysis arisen from cerebral embolism, coronary heart disease, angina pectoris, acute rend function failure, and nephritic syndrome etc., since 1980s. It has been collected in "Pharmacopoeia of P. R. China (2005)". Our research group have reinvestigated and recognized the chemical and bioactive constituents from E. breviscapus since 1992. As the results, we found a series of phenolic compds, such as 1,5-, 3, 5- and 4, 5-dicarffeoylquinic esters, and erigoster A and B, which also possessed same bioactivities with sculellarin isolated and identified by Guan and Zhang([4.5]) in 1980s. Based on the above investigation, the new drug "Injection of Dengzhanxixin Phenols" developed by our research team has completed phase III clinical trial in June 2007. The production certificate is in application. This new drug, with clear bioactive ingredient composition, well-controlled quality, solid therapeutic effect, and complete intellectual property, is believed as new generation drug in the treatment of brain and heart vas related diseases.
出版日期: 2009
卷号: 21, 期号:1, 页码:77-83
语种: 英语
收录类别: SCI
学科分类: Chemistry, Multidisciplinary
ISSN号: 1005-281X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2875
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

Recommended Citation:
Sun, HD; Zhao, QS.A Drug for Treating Cardio-Cerebrovascular Diseases-Phenolic Compds of Erigeron breviscapus,PROGRESS IN CHEMISTRY,2009,21(1):77-83
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