Bioactive ent-kaurane diterpenoids from Isodon serra
Wan, Jun; Liu, Miao; Jiang, Hua-Yi; Yang, Jin; Du, Xue; Li, Xiao-Nian; Wang, Wei-Guang; Li, Yan; Pu, Jian-Xin; Sun, Han-Dong
Source PublicationPHYTOCHEMISTRY
AbstractNine 7,20-epoxy-ent-kaurane diterpenoids (15-acetylmegathyrin B, serrin E, 14 beta-hydroxyrabdocoestin A, serrin F, serrin G, 11-epi-rabdocoestin A, serrin H, serrin I, and 15-acetylenanderianin N), along with seven known ones, were isolated from the aerial parts of Isodon serra. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configuration of 15-acetylmegathyrin B was determined by signal-crystal X-ray diffraction. All of these compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). Serrin F, rabdocoestin B and 1 alpha,11 beta-dihydroxy-1 alpha,11 beta-acetonide-7 alpha,20-epoxy-ent-kaur-16-en-15-one showed cytotoxic activities against all cell lines, with IC50 values ranging from 0.7 to 4.6 mu M; serrin F also strongly inhibited NO production in LPS-stimulated RAW264.7 cells. Otherwise, 14 beta-hydroxyrabdocoestin A, serrins H and I, as well as enanderianin N and megathyrin B, also exhibited inhibitory effects towards NO production, while no cytotoxicity against five cell lines was detected. (C) 2016 Elsevier Ltd. All rights reserved.
KeywordIsodon Serra Lamiaceae Cytotoxic Activity 7 Anti-inflammatory 20-epoxy-ent-kaurane Diterpenoids
Indexed BySCI
WOS IDWOS:000383302900024
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GB/T 7714
Wan, Jun,Liu, Miao,Jiang, Hua-Yi,et al. Bioactive ent-kaurane diterpenoids from Isodon serra[J]. PHYTOCHEMISTRY,2016,130:244-251.
APA Wan, Jun.,Liu, Miao.,Jiang, Hua-Yi.,Yang, Jin.,Du, Xue.,...&Sun, Han-Dong.(2016).Bioactive ent-kaurane diterpenoids from Isodon serra.PHYTOCHEMISTRY,130,244-251.
MLA Wan, Jun,et al."Bioactive ent-kaurane diterpenoids from Isodon serra".PHYTOCHEMISTRY 130(2016):244-251.
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