Bioactive ent-kaurane diterpenoids from Isodon serra
Wan, Jun; Liu, Miao; Jiang, Hua-Yi; Yang, Jin; Du, Xue; Li, Xiao-Nian; Wang, Wei-Guang; Li, Yan; Pu, Jian-Xin; Sun, Han-Dong
2016-10-01
Source PublicationPHYTOCHEMISTRY
Volume130Pages:244-251
AbstractNine 7,20-epoxy-ent-kaurane diterpenoids (15-acetylmegathyrin B, serrin E, 14 beta-hydroxyrabdocoestin A, serrin F, serrin G, 11-epi-rabdocoestin A, serrin H, serrin I, and 15-acetylenanderianin N), along with seven known ones, were isolated from the aerial parts of Isodon serra. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configuration of 15-acetylmegathyrin B was determined by signal-crystal X-ray diffraction. All of these compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). Serrin F, rabdocoestin B and 1 alpha,11 beta-dihydroxy-1 alpha,11 beta-acetonide-7 alpha,20-epoxy-ent-kaur-16-en-15-one showed cytotoxic activities against all cell lines, with IC50 values ranging from 0.7 to 4.6 mu M; serrin F also strongly inhibited NO production in LPS-stimulated RAW264.7 cells. Otherwise, 14 beta-hydroxyrabdocoestin A, serrins H and I, as well as enanderianin N and megathyrin B, also exhibited inhibitory effects towards NO production, while no cytotoxicity against five cell lines was detected. (C) 2016 Elsevier Ltd. All rights reserved.
KeywordIsodon Serra Lamiaceae Cytotoxic Activity 7 Anti-inflammatory 20-epoxy-ent-kaurane Diterpenoids
DOI10.1016/j.phytochem.2016.05.014
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000383302900024
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/28604
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Wan, Jun,Liu, Miao,Jiang, Hua-Yi,et al. Bioactive ent-kaurane diterpenoids from Isodon serra[J]. PHYTOCHEMISTRY,2016,130:244-251.
APA Wan, Jun.,Liu, Miao.,Jiang, Hua-Yi.,Yang, Jin.,Du, Xue.,...&Sun, Han-Dong.(2016).Bioactive ent-kaurane diterpenoids from Isodon serra.PHYTOCHEMISTRY,130,244-251.
MLA Wan, Jun,et al."Bioactive ent-kaurane diterpenoids from Isodon serra".PHYTOCHEMISTRY 130(2016):244-251.
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