Bioactive ent-kaurane diterpenoids from Isodon serra

doi:10.1016/j.phytochem.2016.05.014

	Bioactive ent-kaurane diterpenoids from Isodon serra
	Wan, Jun; Liu, Miao; Jiang, Hua-Yi; Yang, Jin; Du, Xue; Li, Xiao-Nian; Wang, Wei-Guang; Li, Yan; Pu, Jian-Xin; Sun, Han-Dong
	2016-10-01
发表期刊	PHYTOCHEMISTRY
卷号	130 页码:244-251
摘要	Nine 7,20-epoxy-ent-kaurane diterpenoids (15-acetylmegathyrin B, serrin E, 14 beta-hydroxyrabdocoestin A, serrin F, serrin G, 11-epi-rabdocoestin A, serrin H, serrin I, and 15-acetylenanderianin N), along with seven known ones, were isolated from the aerial parts of Isodon serra. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configuration of 15-acetylmegathyrin B was determined by signal-crystal X-ray diffraction. All of these compounds were evaluated for their cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). Serrin F, rabdocoestin B and 1 alpha,11 beta-dihydroxy-1 alpha,11 beta-acetonide-7 alpha,20-epoxy-ent-kaur-16-en-15-one showed cytotoxic activities against all cell lines, with IC50 values ranging from 0.7 to 4.6 mu M; serrin F also strongly inhibited NO production in LPS-stimulated RAW264.7 cells. Otherwise, 14 beta-hydroxyrabdocoestin A, serrins H and I, as well as enanderianin N and megathyrin B, also exhibited inhibitory effects towards NO production, while no cytotoxicity against five cell lines was detected. (C) 2016 Elsevier Ltd. All rights reserved.
关键词	Isodon Serra Lamiaceae Cytotoxic Activity 7 Anti-inflammatory 20-epoxy-ent-kaurane Diterpenoids
DOI	10.1016/j.phytochem.2016.05.014
收录类别	SCI
语种	英语
WOS记录号	WOS:000383302900024
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/28604
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Wan, Jun,Liu, Miao,Jiang, Hua-Yi,et al. Bioactive ent-kaurane diterpenoids from Isodon serra[J]. PHYTOCHEMISTRY,2016,130:244-251.
APA	Wan, Jun.,Liu, Miao.,Jiang, Hua-Yi.,Yang, Jin.,Du, Xue.,...&Sun, Han-Dong.(2016).Bioactive ent-kaurane diterpenoids from Isodon serra.PHYTOCHEMISTRY,130,244-251.
MLA	Wan, Jun,et al."Bioactive ent-kaurane diterpenoids from Isodon serra".PHYTOCHEMISTRY 130(2016):244-251.

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