Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone

doi:10.1038/srep32748

	Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone
	Qin, Xu-Jie; Yan, Huan; Ni, Wei; Yu, Mu-Yuan; Khan, Afsar; Liu, Hui; Zhang, Hong-Xia; He, Li; Hao, Xiao-Jiang; Di, Ying-Tong; Liu, Hai-Yang
	2016-09-02
发表期刊	SCIENTIFIC REPORTS
卷号	6
摘要	Three new meroterpenoids, guajavadials A-C (1-3), were isolated from Psidium guajava cultivated in temperate zone. Their structures were established by extensive spectroscopic evidence and electronic circular dichroism (ECD) calculations. Guajavadial A (1) represents a novel skeleton of the 3,5-diformylbenzyl phloroglucinol-coupled monoterpenoid, while guajavadials B (2) and C (3) are new adducts of the 3,5-diformylbenzyl phloroglucinol and a sesquiterpene with different coupling models. The plausible biosynthetic pathways as well as antimicrobial and cytotoxic activities of these meroterpenoids are also discussed. All these isolates exhibited moderate cytotoxicities against five human cancer cell lines, with 3 being most effective with an IC50 value of 3.54 mu M toward SMMC-7721 cell lines.
DOI	10.1038/srep32748
收录类别	SCI
语种	英语
WOS记录号	WOS:000382397500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/28597
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Qin, Xu-Jie,Yan, Huan,Ni, Wei,et al. Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone[J]. SCIENTIFIC REPORTS,2016,6.
APA	Qin, Xu-Jie.,Yan, Huan.,Ni, Wei.,Yu, Mu-Yuan.,Khan, Afsar.,...&Liu, Hai-Yang.(2016).Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone.SCIENTIFIC REPORTS,6.
MLA	Qin, Xu-Jie,et al."Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone".SCIENTIFIC REPORTS 6(2016).

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