Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone
Qin, Xu-Jie; Yan, Huan; Ni, Wei; Yu, Mu-Yuan; Khan, Afsar; Liu, Hui; Zhang, Hong-Xia; He, Li; Hao, Xiao-Jiang; Di, Ying-Tong; Liu, Hai-Yang
2016-09-02
发表期刊SCIENTIFIC REPORTS
卷号6
摘要Three new meroterpenoids, guajavadials A-C (1-3), were isolated from Psidium guajava cultivated in temperate zone. Their structures were established by extensive spectroscopic evidence and electronic circular dichroism (ECD) calculations. Guajavadial A (1) represents a novel skeleton of the 3,5-diformylbenzyl phloroglucinol-coupled monoterpenoid, while guajavadials B (2) and C (3) are new adducts of the 3,5-diformylbenzyl phloroglucinol and a sesquiterpene with different coupling models. The plausible biosynthetic pathways as well as antimicrobial and cytotoxic activities of these meroterpenoids are also discussed. All these isolates exhibited moderate cytotoxicities against five human cancer cell lines, with 3 being most effective with an IC50 value of 3.54 mu M toward SMMC-7721 cell lines.
资助信息National Natural Science Foundation of China(31570363; Innovation Team of Ministry of Education of China(IRT13067); 31600283; 81573323)
DOI10.1038/srep32748
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000382397500001
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/28597
专题植物化学与西部植物资源持续利用国家重点实验室
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Qin, Xu-Jie,Yan, Huan,Ni, Wei,et al. Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone[J]. SCIENTIFIC REPORTS,2016,6.
APA Qin, Xu-Jie.,Yan, Huan.,Ni, Wei.,Yu, Mu-Yuan.,Khan, Afsar.,...&Liu, Hai-Yang.(2016).Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone.SCIENTIFIC REPORTS,6.
MLA Qin, Xu-Jie,et al."Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone".SCIENTIFIC REPORTS 6(2016).
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