Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy

doi:10.1021/acs.orglett.61301654

	Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy
	Ren, Jian; Shi, Xin; Li, Xiao-Nian; Li, Lai-Wei; Su, Jia; Shao, Li-Dong; Zhao, Qin-Shi
	2016-08-19
发表期刊	ORGANIC LETTERS
卷号	18 期号:16 页码:3948-3951
摘要	An efficient reaction tool box was developed for the synthesis of skeletally diverse and stereochemically complex templates for a small-molecule library based on the common synthon Q, which was prepared from hemslecin A in four steps. The reaction tool box comprises three acid promoted rearrangements: semipinacol, Wagner-Meerwein, and cyclopropylmethyl cation rearrangements. More,importantly, a Mn-mediated C-H oxidation was developed to achieve a high level of complexity, which provides a new entry for C-H functionalization of inert angular methyl groups in the chemistry of triterpenes. Our reaction-discovery strategy based on hemslecin A provides a basis for the inherent chemistry of triterpenes and could be applied for the further transformation of triterpenes.
DOI	10.1021/acs.orglett.61301654
收录类别	SCI
语种	英语
WOS记录号	WOS:000381847500004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/28592
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Ren, Jian,Shi, Xin,Li, Xiao-Nian,et al. Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy[J]. ORGANIC LETTERS,2016,18(16):3948-3951.
APA	Ren, Jian.,Shi, Xin.,Li, Xiao-Nian.,Li, Lai-Wei.,Su, Jia.,...&Zhao, Qin-Shi.(2016).Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy.ORGANIC LETTERS,18(16),3948-3951.
MLA	Ren, Jian,et al."Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy".ORGANIC LETTERS 18.16(2016):3948-3951.

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