Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy
Ren, Jian; Shi, Xin; Li, Xiao-Nian; Li, Lai-Wei; Su, Jia; Shao, Li-Dong; Zhao, Qin-Shi
2016-08-19
Source PublicationORGANIC LETTERS
Volume18Issue:16Pages:3948-3951
AbstractAn efficient reaction tool box was developed for the synthesis of skeletally diverse and stereochemically complex templates for a small-molecule library based on the common synthon Q, which was prepared from hemslecin A in four steps. The reaction tool box comprises three acid promoted rearrangements: semipinacol, Wagner-Meerwein, and cyclopropylmethyl cation rearrangements. More,importantly, a Mn-mediated C-H oxidation was developed to achieve a high level of complexity, which provides a new entry for C-H functionalization of inert angular methyl groups in the chemistry of triterpenes. Our reaction-discovery strategy based on hemslecin A provides a basis for the inherent chemistry of triterpenes and could be applied for the further transformation of triterpenes.
DOI10.1021/acs.orglett.61301654
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000381847500004
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/28592
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Ren, Jian,Shi, Xin,Li, Xiao-Nian,et al. Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy[J]. ORGANIC LETTERS,2016,18(16):3948-3951.
APA Ren, Jian.,Shi, Xin.,Li, Xiao-Nian.,Li, Lai-Wei.,Su, Jia.,...&Zhao, Qin-Shi.(2016).Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy.ORGANIC LETTERS,18(16),3948-3951.
MLA Ren, Jian,et al."Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy".ORGANIC LETTERS 18.16(2016):3948-3951.
Files in This Item: Download All
File Name/Size DocType Version Access License
acs.orglett.pdf(390KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ren, Jian]'s Articles
[Shi, Xin]'s Articles
[Li, Xiao-Nian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ren, Jian]'s Articles
[Shi, Xin]'s Articles
[Li, Xiao-Nian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ren, Jian]'s Articles
[Shi, Xin]'s Articles
[Li, Xiao-Nian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: acs.orglett.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.