Collective formal synthesis of (+/-)-rhynchophylline and homologues

doi:10.1039/c6ra12766e

	Collective formal synthesis of (+/-)-rhynchophylline and homologues
	Xu, Jun1 ; Shao, Li-Dong 1; Shi, Xin 1,2; Ren, Jian 1,2; Xia, Chengfeng 1; Zhao, Qin-Shi1
	2016
发表期刊	RSC ADVANCES
卷号	6 期号:68 页码:63131-63135
摘要	A collective formal synthesis approach to bioactive oxindole alkaloids, including (+/-)-rhynchophylline, (+/-)-isorhynchophylline, (+/-)-mitraphylline, (+/-)-formosanine, (+/-)-isomitraphylline, and (+/-)-isoformosanine, is completed in a protecting-group free manner. Besides multigram-scaled operations, the notable feature of the synthesis is the application of two one-pot, sequential transformations. Namely, two key tetracyclic intermediates pyridinium salt 9 and monoester 14 were prepared by a one-pot N-alkylation/cross-dehydrogenative coupling sequence and a one-pot Michael/Karpocho sequence with minimal purification, respectively.
DOI	10.1039/c6ra12766e
收录类别	SCI
语种	英语
WOS记录号	WOS:000379493900004
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/28465
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jun,Shao, Li-Dong,Shi, Xin,et al. Collective formal synthesis of (+/-)-rhynchophylline and homologues[J]. RSC ADVANCES,2016,6(68):63131-63135.
APA	Xu, Jun,Shao, Li-Dong,Shi, Xin,Ren, Jian,Xia, Chengfeng,&Zhao, Qin-Shi.(2016).Collective formal synthesis of (+/-)-rhynchophylline and homologues.RSC ADVANCES,6(68),63131-63135.
MLA	Xu, Jun,et al."Collective formal synthesis of (+/-)-rhynchophylline and homologues".RSC ADVANCES 6.68(2016):63131-63135.

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