| Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling | |
Kong, Ling-Mei1,2; Feng, Tao1; Wang, Yuan-Yuan3; Li, Xing-Yao1,4; Ye, Zhen-Nan1,2; An, Tao1,2 ; Qing, Chen5; Luo, Xiao-Dong1; Li, Yan1
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| 2016-03-01 | |
| 发表期刊 | ONCOTARGET
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| 卷号 | 7期号:9页码:10203-10214 |
| 摘要 | Wnt signaling pathway is aberrantly activated in a variety of cancers, especially in colorectal cancer and small molecule antagonists of Wnt/beta-catenin signaling are attractive candidates for developing effective therapeutics. In the present study, we identified Bisleuconothine A, a bisindole alkaloid with an eburnane-aspidosperma type skeleton, as a novel and selective Wnt signaling inhibitor by using a cell-based luciferase assay system. Our study found that Bisleuconothine A down-regulated the endogenous Wnt target gene expression through promoting phosphorylation of beta-catenin and the subsequent inhibition of its nuclear translocation in HCT116 and SW480 colorectal cancer cells. In vitro, Bisleuconothine A inhibited cell proliferation through induction of apoptosis by increasing the cleavage of caspases in HCT116 and SW480 colorectal cancer cells. Moreover, in vivo, Bisleuconothine A dramatically suppressed tumor growth in HCT116 Xenograft. And further analysis showed that Bisleuconothine A suppressed the Wnt target gene expression in HCT116 Xenograft, which was associated with up-regulation of beta-catenin phosphorylation and subsequent Wnt signaling inhibition. Taken together, our study indicated that bisindole alkaloids could be included as a new chemotype of small-molecule Wnt signaling inhibitors, and have great potential to be further developed for anti-tumor agents. |
| 关键词 | Bisleuconothine a Inhibitor Wnt Signaling Colorectal Cancer Cells |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375672900045 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26251 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Harbin Inst Technol Weihai, Weihai 264209, Peoples R China 4.Georgia Regents Univ Hlth Sci Campus, Augusta, GA 30912 USA 5.Kunming Med Univ, Kunming 650500, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, Ling-Mei,Feng, Tao,Wang, Yuan-Yuan,et al. Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling[J]. ONCOTARGET,2016,7(9):10203-10214. |
| APA | Kong, Ling-Mei.,Feng, Tao.,Wang, Yuan-Yuan.,Li, Xing-Yao.,Ye, Zhen-Nan.,...&Li, Yan.(2016).Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling.ONCOTARGET,7(9),10203-10214. |
| MLA | Kong, Ling-Mei,et al."Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling".ONCOTARGET 7.9(2016):10203-10214. |
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| 7190-111166-2-PB.pdf（7290KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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