Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissimum
He, Juan1; Peng, Li-Yan1; Tu, Lin1; Wu, Xing-De1; Dong, Liao-Bing1; Pan, Zheng-Hong2; Chen, Xuan-Qin3; Su, Jia1; Zhao, Yu1; Xu, Gang1; Cheng, Xiao1; Li, Yan1; Zhao, Qin-Shi1
Source PublicationFITOTERAPIA
AbstractSeven new vibsane-type diterpenes, vibsanols C-H (1-6) and vibsanin X (7), together with seven analogues, were isolated from the leaves and twigs of Viburnum odoratissimum. The structures of the new compounds were 'elucidated by extensive spectroscopic methods. All the new compounds were detected for their cytotoxicity. Compound 1 showed significant cytotoxicity against all the tested cell lines (HL-60, SMMC-7721, A-594, MCF7, and SW-480), with IC50 values of 3.35, 4.41, 5.18,1130, and 3.70 M, respectively. Compounds 4 and 5 also displayed significant cytotoxicity against hepatocellular carcinoma SMMC-7721 cell line, with IC50 values of 3.69 and 3.52 M, respectively. (C) 2016 Elsevier B.V. All rights reserved.
KeywordViburnum Odoratissimum Vibsane-type Diterpenes Vibsanols C-h Vibsanin x Cytotoxicity
Indexed BySCI
WOS IDWOS:000372685400036
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Guangxi Inst Bot, Guilin 541006, Peoples R China
3.Kunming Univ Sci & Technol, Kunming 650093, Peoples R China
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He, Juan,Peng, Li-Yan,Tu, Lin,et al. Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissimum[J]. FITOTERAPIA,2016,109:224-229.
APA He, Juan.,Peng, Li-Yan.,Tu, Lin.,Wu, Xing-De.,Dong, Liao-Bing.,...&Zhao, Qin-Shi.(2016).Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissimum.FITOTERAPIA,109,224-229.
MLA He, Juan,et al."Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissimum".FITOTERAPIA 109(2016):224-229.
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