Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum

doi:10.1016/j.fitote.2015.12.017

	Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum
	Jiang, Wei-Wei 1,2; Liu, Yu-Chen 1; Zhang, Zhi-Jun 1; Liu, Yan-Chun1 ; He, Juan 1; Su, Jia 1; Cheng, Xiao 1; Peng, Li-Yan 1; Shao, Li-Dong 1; Wu, Xing-De 1; Yang, Jia-Hui 1; Zhao, Qin-Shi1
	2016-03-01
发表期刊	FITOTERAPIA
卷号	109 页码:155-161
摘要	Seven new fawcettimine-type (1-7) and two new lycopodine-type (8 and 9) Lycopodium alkaloids, as well as 10 known compounds, were isolated from the club moss, Lycopodium obscurum L The structures of obscurumines H-P (1-9) were determined based on high-resolution MS and 1D and 2D NMR data. Compounds 1 and 2 include a new skeleton that is formed via the linkage of C-9-N-2', which is "rarely present in Lycopodium alkaloids. The in vitro acetylcholinesterase (AChE) inhibitory activity assay showed that 5 exhibited weak anti-AChE activity with an IC50 value of 81.0 mu M. Compound 8 exhibited inhibition of the secretion of IL-2 in phytohemagglutinin (PHA) and phorbol myristate acetate (PMA) stimulated Jurkat cells, and the IC50 value was 17.2 mu M. (C) 2015 Elsevier B.V. All rights reserved.
关键词	Lycopodium Obscurum L. Lycopodium Alkaloids Obscurumines H-p Anti-ache Activity Immunosuppressive Activity
DOI	10.1016/j.fitote.2015.12.017
收录类别	SCI
语种	英语
WOS记录号	WOS:000372685400024
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/26188
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Yunnan Agr Univ, Coll Basic Sci & Informat Engn, Kuming 6540201, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Wei-Wei,Liu, Yu-Chen,Zhang, Zhi-Jun,et al. Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum[J]. FITOTERAPIA,2016,109:155-161.
APA	Jiang, Wei-Wei.,Liu, Yu-Chen.,Zhang, Zhi-Jun.,Liu, Yan-Chun.,He, Juan.,...&Zhao, Qin-Shi.(2016).Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum.FITOTERAPIA,109,155-161.
MLA	Jiang, Wei-Wei,et al."Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum".FITOTERAPIA 109(2016):155-161.

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