Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces

doi:10.1021/acs.orglett.6b00074

	Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces
	Yan, Yijun 1; Ma, Ya-Tuan 1; Yang, Jing1 ; Horsman, Geoff P.2; Luo, Dan 1; Ji, Xu1 ; Huang, Sheng-Xiong1
	2016-03-18
发表期刊	ORGANIC LETTERS
卷号	18 期号:6 页码:1254-1257
摘要	Rubrolones are tropolonoid natural products with a unique carbon skeleton. Extensive secondary metabolite analysis of the endophytic Streptomyces sp. KIB-H033 revealed a new class of rubrolone analogue possessing a rare benzoic acid pyridine inner salt moiety. Precursor feeding with [C-13] -acetate revealed a labeling pattern consistent with tropolone moiety construction via type-II PKS chemistry followed by complex oxidative rearrangements. This bacterial biosynthetic route represents a surprising departure from fungal tropolone assembly during stipitatic acid biosynthesis.
DOI	10.1021/acs.orglett.6b00074
收录类别	SCI
语种	英语
WOS记录号	WOS:000372664600010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/26179
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Wilfrid Laurier Univ, Dept Chem & Biochem, Waterloo, ON N2L 3C5, Canada
推荐引用方式 GB/T 7714	Yan, Yijun,Ma, Ya-Tuan,Yang, Jing,et al. Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces[J]. ORGANIC LETTERS,2016,18(6):1254-1257.
APA	Yan, Yijun.,Ma, Ya-Tuan.,Yang, Jing.,Horsman, Geoff P..,Luo, Dan.,...&Huang, Sheng-Xiong.(2016).Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces.ORGANIC LETTERS,18(6),1254-1257.
MLA	Yan, Yijun,et al."Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces".ORGANIC LETTERS 18.6(2016):1254-1257.

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