A new antifungal macrolide from Streptomyces sp KIB-H869 and structure revision of halichomycin
Yu, Zhiyin1,2; Wang, Li1; Yang, Jing1; Zhang, Fan3; Sun, Yun2; Yu, Mingming1; Yan, Yijun1; Ma, Ya-Tuan1; Huang, Sheng-Xiong1
2016-03-23
发表期刊TETRAHEDRON LETTERS
卷号57期号:12页码:1375-1378
摘要A new hygrolidin-type macrolide (1), together with one known derivative, oxohygrolidin (2), were isolated from the culture of Streptomyces sp. KIB-H869. The structure of the new compound was elucidated by means of extensive spectroscopic analysis. Moreover, by the biogenesis ratiocination and NMR data comparison, halichomycin and 2 were confirmed to have the same structure, which corrects the structural misrepresentation of halichomycin. The antifungal activities of the two compounds were evaluated. Published by Elsevier Ltd.
关键词Streptomyces Type 1 Pks Oxohygrolidin Halichomycin Structure Revision
DOI10.1016/j.tetlet.2016.02.061
收录类别SCI
语种英语
WOS记录号WOS:000371941900020
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/26020
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.XinJiang Med Univ, Coll Tradit Chinese Med, Urumqi 830011, Peoples R China
3.North Sichuan Med Univ, Sch Pharm, Nanchong 637007, Sichuan, Peoples R China
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Yu, Zhiyin,Wang, Li,Yang, Jing,et al. A new antifungal macrolide from Streptomyces sp KIB-H869 and structure revision of halichomycin[J]. TETRAHEDRON LETTERS,2016,57(12):1375-1378.
APA Yu, Zhiyin.,Wang, Li.,Yang, Jing.,Zhang, Fan.,Sun, Yun.,...&Huang, Sheng-Xiong.(2016).A new antifungal macrolide from Streptomyces sp KIB-H869 and structure revision of halichomycin.TETRAHEDRON LETTERS,57(12),1375-1378.
MLA Yu, Zhiyin,et al."A new antifungal macrolide from Streptomyces sp KIB-H869 and structure revision of halichomycin".TETRAHEDRON LETTERS 57.12(2016):1375-1378.
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