| Bioactive spirostane glycosides from Tacca plantaginea | |
Liu, Zhen-Hua1,2; Yan, Huan1; Si, Yong-Ai1,2 ; Ni, Wei1; Chen, Yu1,2; He, Li3; Liu, Hai-Yang1
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| 2016-02-01 | |
| 发表期刊 | STEROIDS
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| 卷号 | 106页码:86-92 |
| 摘要 | Eight new spirostane glycosides, taccaosides E-L (2-7, 11, and 14), along with 7 known spirostane glycosides were isolated from the extract of the whole plants of Tacca plantaginea (Hance) Drenth. Their structures were established on the basis of physical data, spectroscopic analysis (MS, 1D and 2D NMR), and chemical methods. The cytotoxicities of the isolates were evaluated in vitro against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 1 had the strongest cytotoxic activity with IC50 values of 1.7 mu M and 1.2 mu M against the two cancer cell lines, respectively. Furthermore, the spirostane glycosides with 17 alpha-hydroxyl group at their aglycones (10, 12, and 15) were tested for the induced platelet aggregation activity. (C) 2015 Elsevier Inc. All rights reserved. |
| 关键词 | Tacca Plantaginea Spirostane Glycosides Taccaosides E-l Cytotoxicity Induced Platelet Aggregation Activity |
| DOI | 10.1016/j.steroids.2015.12.013 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000371191000011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/25981 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhen-Hua,Yan, Huan,Si, Yong-Ai,et al. Bioactive spirostane glycosides from Tacca plantaginea[J]. STEROIDS,2016,106:86-92. |
| APA | Liu, Zhen-Hua.,Yan, Huan.,Si, Yong-Ai.,Ni, Wei.,Chen, Yu.,...&Liu, Hai-Yang.(2016).Bioactive spirostane glycosides from Tacca plantaginea.STEROIDS,106,86-92. |
| MLA | Liu, Zhen-Hua,et al."Bioactive spirostane glycosides from Tacca plantaginea".STEROIDS 106(2016):86-92. |
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