Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization | |
Zhou, Min; Li, Xing-Ren; Tang, Jian-Wei; Liu, Yang; Li, Xiao-Nian; Wu, Bin; Qin, Hong-Bo![]() ![]() ![]() | |
2015-12-18 | |
发表期刊 | ORGANIC LETTERS
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卷号 | 17期号:24页码:6062-6065 |
摘要 | Scopariusicides A (1) and B (2), two novel immunosuppressive unsymmetrical cyclobutane derivatives, were isolated from the aerial parts of Isodon scoparius. Moreover, based on the results of phytochemical investigation, a concise stereocontrolled synthesis of scopariusicide A and its analogues with enhanced biological activities was efficiently achieved using the main diterpenoid (3) isolated from this plant as a readily available starting material. A crossed intermolecular [2 + 2] photocycloaddition and a Pd-catalyzed sp3 C-H bond beta-arylation were used synergistically to access the highly congested unsymmetrical cyclobutane core with four contiguous stereocenters. |
DOI | 10.1021/acs.orglett.5b03079 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000366878300032 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/25330 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
推荐引用方式 GB/T 7714 | Zhou, Min,Li, Xing-Ren,Tang, Jian-Wei,et al. Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization[J]. ORGANIC LETTERS,2015,17(24):6062-6065. |
APA | Zhou, Min.,Li, Xing-Ren.,Tang, Jian-Wei.,Liu, Yang.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2015).Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization.ORGANIC LETTERS,17(24),6062-6065. |
MLA | Zhou, Min,et al."Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization".ORGANIC LETTERS 17.24(2015):6062-6065. |
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