Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear
Zhou, Feng-Jiao; Nian, Yin; Yan, Yongming; Gong, Ye; Luo, Qj; Zhang, Yu; Hou, Bo; Zuo, Zhi-Li; Wang, Shu-Mei; Jiang, He-Hai; Yang, Jian; Cheng, Yong-Xian
2015-06-19
Source PublicationORGANIC LETTERS
Volume17Issue:12Pages:3082-3085
AbstractT-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (+/-)-6 significantly inhibited Ca(v)3.1 TTCC and showed noticeable selectivity against Ca(v)1.2, Ca(v)2.1, Ca(v)2.2, and K(v)11.1 (hERG) channels.
DOI10.1021/acs.orglett.5b01353
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000356845000056
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/24965
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Zhou, Feng-Jiao,Nian, Yin,Yan, Yongming,et al. Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear[J]. ORGANIC LETTERS,2015,17(12):3082-3085.
APA Zhou, Feng-Jiao.,Nian, Yin.,Yan, Yongming.,Gong, Ye.,Luo, Qj.,...&Cheng, Yong-Xian.(2015).Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear.ORGANIC LETTERS,17(12),3082-3085.
MLA Zhou, Feng-Jiao,et al."Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear".ORGANIC LETTERS 17.12(2015):3082-3085.
Files in This Item: Download All
File Name/Size DocType Version Access License
2015625171447469.pdf(619KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhou, Feng-Jiao]'s Articles
[Nian, Yin]'s Articles
[Yan, Yongming]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhou, Feng-Jiao]'s Articles
[Nian, Yin]'s Articles
[Yan, Yongming]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhou, Feng-Jiao]'s Articles
[Nian, Yin]'s Articles
[Yan, Yongming]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 2015625171447469.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.