Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear

doi:10.1021/acs.orglett.5b01353

	Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear
	Zhou, Feng-Jiao; Nian, Yin; Yan, Yongming; Gong, Ye; Luo, Qj; Zhang, Yu; Hou, Bo; Zuo, Zhi-Li; Wang, Shu-Mei; Jiang, He-Hai; Yang, Jian; Cheng, Yong-Xian
	2015-06-19
发表期刊	ORGANIC LETTERS
卷号	17 期号:12 页码:3082-3085
摘要	T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (+/-)-6 significantly inhibited Ca(v)3.1 TTCC and showed noticeable selectivity against Ca(v)1.2, Ca(v)2.1, Ca(v)2.2, and K(v)11.1 (hERG) channels.
DOI	10.1021/acs.orglett.5b01353
收录类别	SCI
语种	英语
WOS记录号	WOS:000356845000056
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/24965
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Zhou, Feng-Jiao,Nian, Yin,Yan, Yongming,et al. Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear[J]. ORGANIC LETTERS,2015,17(12):3082-3085.
APA	Zhou, Feng-Jiao.,Nian, Yin.,Yan, Yongming.,Gong, Ye.,Luo, Qj.,...&Cheng, Yong-Xian.(2015).Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear.ORGANIC LETTERS,17(12),3082-3085.
MLA	Zhou, Feng-Jiao,et al."Two New Classes of 1-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear".ORGANIC LETTERS 17.12(2015):3082-3085.

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