Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis
Ya-Feng, Wang1,2; Xiao-Yan, Wang1,2; Zhe, Ren1,2; Chui-Wen, Qian1,2; Yi-Cheng, Li1,2; Kitazato, Kaio1,3; Qing-Duan, Wang4; Yan, Zhang4; Li-Yun, Zheng4; Jin-Hua, Jiang4; Chong-Ren, Yang5; Qing, Liu5; Ying-Jun, Zhang5; Yi-Fei, Wang1,2
2009-11-01
发表期刊ANTIVIRAL RESEARCH
ISSN0166-3542
卷号84期号:2页码:150-158
摘要Coxsackie virus B3 (CVB3) is believed to be a major contributor to viral myocarditis since virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis. in this study, we investigated the in vitro and in vivo antiviral activities of Phyllaemblicin B, the main ellagitannin compound isolated from Phyllanthus emblica, a Chinese herb medicine, against CVB3. Herein we report that Phyllaemblicin B inhibited CVB3-mediated cytopathic effects on HeLa cells with an IC50 value of 7.75 +/- 0.15 mu g/mL In an in vivo assay, treatment with 12 mg kg(-1) d(-1) Phyllaemblicin B reduced cardiac CVB3 titers, decreased the activities of LDH and CK in murine serum, and alleviated pathological damages of cardiac muscle in myocarditic mice. Moreover, Phyllaemblicin B clearly inhibited CVB3-associated apoptosis effects both in vitro and in vivo. These results show that Phyllaemblicin B exerts significant antiviral activities against Phyllaemblicin B may represent a potential therapeutic agent for viral myocarditis. Therefore CVB3. (C) 2009 Elsevier B.V. All rights reserved.
关键词Coxsackie Virus B3 Viral Myocarditis Phyllaemblicin b Antiviral Effect Apoptosis
资助信息This study was supported by the joint Funds of National Science Foundation of China (U0632010), the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (P2008-KF07, P2008-ZZ08) and "211 grant of the Ministry of Education (MOE)".
学科领域Pharmacology & Pharmacy ; Virology
DOI10.1016/j.antiviral.2009.08.004
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Virology
WOS类目Pharmacology & Pharmacy ; Virology
WOS记录号WOS:000271171800005
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2399
专题资源植物与生物技术所级重点实验室
作者单位1.Jinan Univ, Inst Pharmacol Sci, Guangzhou 510630, Guangdong, Peoples R China
2.Natl Engn Res Ctr Genet Med, Guangzhou 510630, Guangdong, Peoples R China
3.Nagasaki Univ, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Lab Mol Biol Infect Agents, Nagasaki 852, Japan
4.Zhengzhou Univ, Henan Acad Med & Pharmaceut Sci, Zhengzhou 450000, Henan, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
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Ya-Feng, Wang,Xiao-Yan, Wang,Zhe, Ren,et al. Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis[J]. ANTIVIRAL RESEARCH,2009,84(2):150-158.
APA Ya-Feng, Wang.,Xiao-Yan, Wang.,Zhe, Ren.,Chui-Wen, Qian.,Yi-Cheng, Li.,...&Yi-Fei, Wang.(2009).Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis.ANTIVIRAL RESEARCH,84(2),150-158.
MLA Ya-Feng, Wang,et al."Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis".ANTIVIRAL RESEARCH 84.2(2009):150-158.
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