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题名: Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis
作者: Ya-Feng, Wang1, 2; Xiao-Yan, Wang1, 2; Zhe, Ren1, 2; Chui-Wen, Qian1, 2; Yi-Cheng, Li1, 2; Kitazato, Kaio1, 3; Qing-Duan, Wang4; Yan, Zhang4; Li-Yun, Zheng4; Jin-Hua, Jiang4; Chong-Ren, Yang5; Qing, Liu5; null(张颖君)5; Yi-Fei, Wang1, 2
刊名: ANTIVIRAL RESEARCH
关键词: Coxsackie virus B3 ; Viral myocarditis ; Phyllaemblicin B ; Antiviral effect ; Apoptosis
英文摘要: Coxsackie virus B3 (CVB3) is believed to be a major contributor to viral myocarditis since virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis. in this study, we investigated the in vitro and in vivo antiviral activities of Phyllaemblicin B, the main ellagitannin compound isolated from Phyllanthus emblica, a Chinese herb medicine, against CVB3. Herein we report that Phyllaemblicin B inhibited CVB3-mediated cytopathic effects on HeLa cells with an IC50 value of 7.75 +/- 0.15 mu g/mL In an in vivo assay, treatment with 12 mg kg(-1) d(-1) Phyllaemblicin B reduced cardiac CVB3 titers, decreased the activities of LDH and CK in murine serum, and alleviated pathological damages of cardiac muscle in myocarditic mice. Moreover, Phyllaemblicin B clearly inhibited CVB3-associated apoptosis effects both in vitro and in vivo. These results show that Phyllaemblicin B exerts significant antiviral activities against Phyllaemblicin B may represent a potential therapeutic agent for viral myocarditis. Therefore CVB3. (C) 2009 Elsevier B.V. All rights reserved.
出版日期: 2009-11-01
卷号: 84, 期号:2, 页码:150-158
DOI标识: 10.1016/j.antiviral.2009.08.004
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy; Virology
ISSN号: 0166-3542
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2399
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Jinan Univ, Inst Pharmacol Sci, Guangzhou 510630, Guangdong, Peoples R China
2.Natl Engn Res Ctr Genet Med, Guangzhou 510630, Guangdong, Peoples R China
3.Nagasaki Univ, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Lab Mol Biol Infect Agents, Nagasaki 852, Japan
4.Zhengzhou Univ, Henan Acad Med & Pharmaceut Sci, Zhengzhou 450000, Henan, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Ya-Feng, W; Xiao-Yan, W; Zhe, R; Chui-Wen, Q; Yi-Cheng, L; Kitazato, K; Qing-Duan, W; Yan, Z; Li-Yun, Z; Jin-Hua, J; Chong-Ren, Y; Qing, L; Ying-Jun, Z; Yi-Fei, W.Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis,ANTIVIRAL RESEARCH,2009,84(2):150-158
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