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Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis
Ya-Feng, Wang1,2; Xiao-Yan, Wang1,2; Zhe, Ren1,2; Chui-Wen, Qian1,2; Yi-Cheng, Li1,2; Kitazato, Kaio1,3; Qing-Duan, Wang4; Yan, Zhang4; Li-Yun, Zheng4; Jin-Hua, Jiang4; Chong-Ren, Yang5; Qing, Liu5; Ying-Jun, Zhang5; Yi-Fei, Wang1,2
AbstractCoxsackie virus B3 (CVB3) is believed to be a major contributor to viral myocarditis since virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis. in this study, we investigated the in vitro and in vivo antiviral activities of Phyllaemblicin B, the main ellagitannin compound isolated from Phyllanthus emblica, a Chinese herb medicine, against CVB3. Herein we report that Phyllaemblicin B inhibited CVB3-mediated cytopathic effects on HeLa cells with an IC50 value of 7.75 +/- 0.15 mu g/mL In an in vivo assay, treatment with 12 mg kg(-1) d(-1) Phyllaemblicin B reduced cardiac CVB3 titers, decreased the activities of LDH and CK in murine serum, and alleviated pathological damages of cardiac muscle in myocarditic mice. Moreover, Phyllaemblicin B clearly inhibited CVB3-associated apoptosis effects both in vitro and in vivo. These results show that Phyllaemblicin B exerts significant antiviral activities against Phyllaemblicin B may represent a potential therapeutic agent for viral myocarditis. Therefore CVB3. (C) 2009 Elsevier B.V. All rights reserved.
KeywordCoxsackie Virus B3 Viral Myocarditis Phyllaemblicin b Antiviral Effect Apoptosis
Subject AreaPharmacology & Pharmacy ; Virology
Indexed BySCI
WOS Research AreaPharmacology & Pharmacy ; Virology
WOS SubjectPharmacology & Pharmacy ; Virology
WOS IDWOS:000271171800005
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Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Jinan Univ, Inst Pharmacol Sci, Guangzhou 510630, Guangdong, Peoples R China
2.Natl Engn Res Ctr Genet Med, Guangzhou 510630, Guangdong, Peoples R China
3.Nagasaki Univ, Dept Mol Microbiol & Immunol, Grad Sch Biomed Sci, Lab Mol Biol Infect Agents, Nagasaki 852, Japan
4.Zhengzhou Univ, Henan Acad Med & Pharmaceut Sci, Zhengzhou 450000, Henan, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Ya-Feng, Wang,Xiao-Yan, Wang,Zhe, Ren,et al. Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis[J]. ANTIVIRAL RESEARCH,2009,84(2):150-158.
APA Ya-Feng, Wang.,Xiao-Yan, Wang.,Zhe, Ren.,Chui-Wen, Qian.,Yi-Cheng, Li.,...&Yi-Fei, Wang.(2009).Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis.ANTIVIRAL RESEARCH,84(2),150-158.
MLA Ya-Feng, Wang,et al."Phyllaemblicin B inhibits Coxsackie virus B3 induced apoptosis and myocarditis".ANTIVIRAL RESEARCH 84.2(2009):150-158.
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