中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis
作者: Ye, Bai-Xin; Deng, Xu; Shao, Li-Dong; Lu, Ying; Xiao, Run; Liu, Yi-Jie; Jin, Yi; Xie, Yin-Yin; Zhao, Yan; Luo, Liu-Fei; Ma, Shun; Gao, Ming; Zhang, Lian-Ru; He, Juan; Zhang, Wei-Na; Chen, Yi; null(夏成峰); Deng, Min; Liu, Ting-Xi; null(赵勤实); Chen, Sai-Juan; Chen, Zhu
刊名: JOURNAL OF IMMUNOLOGY
出版日期: 2015-05-01
卷号: 194, 期号:9, 页码:4489-4497
学科分类: Immunology
DOI: 10.4049/jimmunol.1402798
通讯作者: Chen,Z (reprint author),Shanghai Jiao Tong Univ,RuiJin Hosp,Sch Med,197 Rui Jin Rd 2,Shanghai 200025,Peoples R China. ; qinshizhao@mail.kib.ac.cn ; sjchen@stn.sh.cn ; zchen@stn.sh.cn
文章类型: Article
英文摘要: Interstitial leukocyte migration plays a critical role in inflammation and offers a therapeutic target for treating inflammation-associated diseases such as multiple sclerosis. Identifying small molecules to inhibit undesired leukocyte migration provides promise for the treatment of these disorders. In this study, we identified vibsanin B, a novel macrocyclic diterpenoid isolated from Viburnum odoratissimum Ker-Gawl, that inhibited zebrafish interstitial leukocyte migration using a transgenic zebrafish line (TG:zlyz-enhanced GFP). We found that vibsanin B preferentially binds to heat shock protein (HSP)90b. At the molecular level, inactivation of HSP90 can mimic vibsanin B's effect of inhibiting interstitial leukocyte migration. Furthermore, we demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leukocyte infiltration into their CNS. In summary, vibsanin B is a novel lead compound that preferentially targets HSP90 beta and inhibits interstitial leukocyte migration, offering a promising drug lead for treating inflammation-associated diseases.
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; BIOLOGICAL-ACTIVITIES ; MULTIPLE-SCLEROSIS ; NATURAL-PRODUCTS ; DRUG DISCOVERY ; CELL-MIGRATION ; ZEBRAFISH ; INFLAMMATION ; MOTILITY ; CANCER
收录类别: SCI
项目资助者: Chinese National Key Basic Research Project 973 Grant [2013CB966800] ; Chinese Ministry of Health [201202003] ; Mega-Projects of Scientific Research for the 12th Five-Year Plan [2013ZX09303302] ; State Key Laboratories Project of Excellence [81123005]
语种: 英语
WOS记录号: WOS:000353727400047
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21355
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
J Immunol-2015-Ye-4489-97.pdf(1516KB)期刊论文作者接受稿开放获取View Download
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ye, Bai-Xin]'s Articles
[Deng, Xu]'s Articles
[Shao, Li-Dong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ye, Bai-Xin]‘s Articles
[Deng, Xu]‘s Articles
[Shao, Li-Dong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: J Immunol-2015-Ye-4489-97.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace