Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis

doi:10.4049/jimmunol.1402798

	Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis
	Ye, Bai-Xin; Deng, Xu; Shao, Li-Dong; Lu, Ying; Xiao, Run; Liu, Yi-Jie; Jin, Yi; Xie, Yin-Yin; Zhao, Yan; Luo, Liu-Fei; Ma, Shun; Gao, Ming; Zhang, Lian-Ru; He, Juan; Zhang, Wei-Na; Chen, Yi; Xia, Cheng-Feng; Deng, Min; Liu, Ting-Xi; Zhao, Qin-Shi; Chen, Sai-Juan; Chen, Zhu; Chen,Z (reprint author),Shanghai Jiao Tong Univ,RuiJin Hosp,Sch Med,197 Rui Jin Rd 2,Shanghai 200025,Peoples R China.; qinshizhao@mail.kib.ac.cn; sjchen@stn.sh.cn; zchen@stn.sh.cn
	2015-05-01
发表期刊	JOURNAL OF IMMUNOLOGY
卷号	194 期号:9 页码:4489-4497
摘要	Interstitial leukocyte migration plays a critical role in inflammation and offers a therapeutic target for treating inflammation-associated diseases such as multiple sclerosis. Identifying small molecules to inhibit undesired leukocyte migration provides promise for the treatment of these disorders. In this study, we identified vibsanin B, a novel macrocyclic diterpenoid isolated from Viburnum odoratissimum Ker-Gawl, that inhibited zebrafish interstitial leukocyte migration using a transgenic zebrafish line (TG:zlyz-enhanced GFP). We found that vibsanin B preferentially binds to heat shock protein (HSP)90b. At the molecular level, inactivation of HSP90 can mimic vibsanin B's effect of inhibiting interstitial leukocyte migration. Furthermore, we demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leukocyte infiltration into their CNS. In summary, vibsanin B is a novel lead compound that preferentially targets HSP90 beta and inhibits interstitial leukocyte migration, offering a promising drug lead for treating inflammation-associated diseases.
学科领域	Immunology
DOI	10.4049/jimmunol.1402798
收录类别	SCI
语种	英语
WOS记录号	WOS:000353727400047
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/21355
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Chen,Z (reprint author),Shanghai Jiao Tong Univ,RuiJin Hosp,Sch Med,197 Rui Jin Rd 2,Shanghai 200025,Peoples R China.; qinshizhao@mail.kib.ac.cn; sjchen@stn.sh.cn; zchen@stn.sh.cn
推荐引用方式 GB/T 7714	Ye, Bai-Xin,Deng, Xu,Shao, Li-Dong,et al. Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis[J]. JOURNAL OF IMMUNOLOGY,2015,194(9):4489-4497.
APA	Ye, Bai-Xin.,Deng, Xu.,Shao, Li-Dong.,Lu, Ying.,Xiao, Run.,...&zchen@stn.sh.cn.(2015).Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis.JOURNAL OF IMMUNOLOGY,194(9),4489-4497.
MLA	Ye, Bai-Xin,et al."Vibsanin B Preferentially Targets HSP90b, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis".JOURNAL OF IMMUNOLOGY 194.9(2015):4489-4497.

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