Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors
Chen, Duozhi; Cai, Jieyun; Yin, Junlin; Jiang, Jiandong; Jing, Chenxu; Zhu, Yanping; Cheng, Junjun; Di, Yingtong; Zhang, Yu; Cao, Mingming; Li, Shunlin; Peng, Zonggen; Hao, Xiaojiang; Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
2015
Source PublicationFUTURE MEDICINAL CHEMISTRY
Volume7Issue:5Pages:561-570
AbstractBackground: A new series of potential phenanthridine hepatitis C virus (HCV) inhibitors which work by suppressing Hsc70 expression in the host cell was designed and synthesized from lycorine. Results: Thirty-one new potential phenanthridine HCV inhibitors were synthesized and five of these compounds exhibited good anti-HCV activity and these inhibitors probably inhibit HCV by downregulating the host Hsc70 expression. Structure-activity analysis of these compounds revealed that the double bond between C-11 and C-12 and the substituents at C-8 and C-9 are important for their activity against HCV. Conclusion: Suppression of Hsc70 expression in the host cell to limit HCV replication is a potential anti-HCV strategy. Phenanthridines are probably the HCV inhibitors with this mode of action.
Subject AreaChemistry, Medicinal
DOI10.4155/fmc.15.14
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000354104900004
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/21351
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorHao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
Recommended Citation
GB/T 7714
Chen, Duozhi,Cai, Jieyun,Yin, Junlin,et al. Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors[J]. FUTURE MEDICINAL CHEMISTRY,2015,7(5):561-570.
APA Chen, Duozhi.,Cai, Jieyun.,Yin, Junlin.,Jiang, Jiandong.,Jing, Chenxu.,...&haoxj@mail.kib.ac.cn.(2015).Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors.FUTURE MEDICINAL CHEMISTRY,7(5),561-570.
MLA Chen, Duozhi,et al."Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors".FUTURE MEDICINAL CHEMISTRY 7.5(2015):561-570.
Files in This Item: Download All
File Name/Size DocType Version Access License
chen20153.pdf(1560KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, Duozhi]'s Articles
[Cai, Jieyun]'s Articles
[Yin, Junlin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, Duozhi]'s Articles
[Cai, Jieyun]'s Articles
[Yin, Junlin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, Duozhi]'s Articles
[Cai, Jieyun]'s Articles
[Yin, Junlin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: chen20153.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.