| Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors | |
Chen, Duozhi; Cai, Jieyun; Yin, Junlin; Jiang, Jiandong; Jing, Chenxu; Zhu, Yanping; Cheng, Junjun; Di, Yingtong ; Zhang, Yu; Cao, Mingming; Li, Shunlin; Peng, Zonggen; Hao, Xiaojiang; Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
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| 2015 | |
| Source Publication | FUTURE MEDICINAL CHEMISTRY
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| Volume | 7Issue:5Pages:561-570 |
| Abstract | Background: A new series of potential phenanthridine hepatitis C virus (HCV) inhibitors which work by suppressing Hsc70 expression in the host cell was designed and synthesized from lycorine. Results: Thirty-one new potential phenanthridine HCV inhibitors were synthesized and five of these compounds exhibited good anti-HCV activity and these inhibitors probably inhibit HCV by downregulating the host Hsc70 expression. Structure-activity analysis of these compounds revealed that the double bond between C-11 and C-12 and the substituents at C-8 and C-9 are important for their activity against HCV. Conclusion: Suppression of Hsc70 expression in the host cell to limit HCV replication is a potential anti-HCV strategy. Phenanthridines are probably the HCV inhibitors with this mode of action. |
| Subject Area | Chemistry, Medicinal |
| DOI | 10.4155/fmc.15.14 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000354104900004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/21351 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn |
| Recommended Citation GB/T 7714 | Chen, Duozhi,Cai, Jieyun,Yin, Junlin,et al. Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors[J]. FUTURE MEDICINAL CHEMISTRY,2015,7(5):561-570. |
| APA | Chen, Duozhi.,Cai, Jieyun.,Yin, Junlin.,Jiang, Jiandong.,Jing, Chenxu.,...&haoxj@mail.kib.ac.cn.(2015).Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors.FUTURE MEDICINAL CHEMISTRY,7(5),561-570. |
| MLA | Chen, Duozhi,et al."Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors".FUTURE MEDICINAL CHEMISTRY 7.5(2015):561-570. |
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| chen20153.pdf（1560KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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