Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors | |
Chen, Duozhi; Cai, Jieyun; Yin, Junlin; Jiang, Jiandong; Jing, Chenxu; Zhu, Yanping; Cheng, Junjun; Di, Yingtong; Zhang, Yu; Cao, Mingming; Li, Shunlin; Peng, Zonggen; Hao, Xiaojiang; Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn | |
2015 | |
发表期刊 | FUTURE MEDICINAL CHEMISTRY |
卷号 | 7期号:5页码:561-570 |
摘要 | Background: A new series of potential phenanthridine hepatitis C virus (HCV) inhibitors which work by suppressing Hsc70 expression in the host cell was designed and synthesized from lycorine. Results: Thirty-one new potential phenanthridine HCV inhibitors were synthesized and five of these compounds exhibited good anti-HCV activity and these inhibitors probably inhibit HCV by downregulating the host Hsc70 expression. Structure-activity analysis of these compounds revealed that the double bond between C-11 and C-12 and the substituents at C-8 and C-9 are important for their activity against HCV. Conclusion: Suppression of Hsc70 expression in the host cell to limit HCV replication is a potential anti-HCV strategy. Phenanthridines are probably the HCV inhibitors with this mode of action. |
学科领域 | Chemistry, Medicinal |
DOI | 10.4155/fmc.15.14 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000354104900004 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/21351 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
通讯作者 | Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn |
推荐引用方式 GB/T 7714 | Chen, Duozhi,Cai, Jieyun,Yin, Junlin,et al. Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors[J]. FUTURE MEDICINAL CHEMISTRY,2015,7(5):561-570. |
APA | Chen, Duozhi.,Cai, Jieyun.,Yin, Junlin.,Jiang, Jiandong.,Jing, Chenxu.,...&haoxj@mail.kib.ac.cn.(2015).Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors.FUTURE MEDICINAL CHEMISTRY,7(5),561-570. |
MLA | Chen, Duozhi,et al."Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors".FUTURE MEDICINAL CHEMISTRY 7.5(2015):561-570. |
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