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题名: Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors
作者: Chen, Duozhi; Cai, Jieyun; Yin, Junlin; Jiang, Jiandong; Jing, Chenxu; Zhu, Yanping; Cheng, Junjun; null(邸迎彤); Zhang, Yu; Cao, Mingming; Li, Shunlin; Peng, Zonggen; null(郝小江)
刊名: FUTURE MEDICINAL CHEMISTRY
出版日期: 2015
卷号: 7, 期号:5, 页码:561-570
学科分类: Chemistry, Medicinal
DOI: 10.4155/fmc.15.14
通讯作者: Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; haoxj@mail.kib.ac.cn
文章类型: Article
英文摘要: Background: A new series of potential phenanthridine hepatitis C virus (HCV) inhibitors which work by suppressing Hsc70 expression in the host cell was designed and synthesized from lycorine. Results: Thirty-one new potential phenanthridine HCV inhibitors were synthesized and five of these compounds exhibited good anti-HCV activity and these inhibitors probably inhibit HCV by downregulating the host Hsc70 expression. Structure-activity analysis of these compounds revealed that the double bond between C-11 and C-12 and the substituents at C-8 and C-9 are important for their activity against HCV. Conclusion: Suppression of Hsc70 expression in the host cell to limit HCV replication is a potential anti-HCV strategy. Phenanthridines are probably the HCV inhibitors with this mode of action.
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: RESISTANCE ; REPLICATION ; AMARYLLIDACEAE ; INFECTION ; PROGRESS ; RNA
收录类别: SCI
项目资助者: National Natural Science Foundation of China [81402828, 21432010] ; "Xi Bu Zhi Guang" Foundation of The Chinese Academy of Sciences
语种: 英语
WOS记录号: WOS:000354104900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21351
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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