Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors
Chen, Duozhi; Cai, Jieyun; Yin, Junlin; Jiang, Jiandong; Jing, Chenxu; Zhu, Yanping; Cheng, Junjun; Di, Yingtong; Zhang, Yu; Cao, Mingming; Li, Shunlin; Peng, Zonggen; Hao, Xiaojiang; Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
2015
发表期刊FUTURE MEDICINAL CHEMISTRY
卷号7期号:5页码:561-570
摘要Background: A new series of potential phenanthridine hepatitis C virus (HCV) inhibitors which work by suppressing Hsc70 expression in the host cell was designed and synthesized from lycorine. Results: Thirty-one new potential phenanthridine HCV inhibitors were synthesized and five of these compounds exhibited good anti-HCV activity and these inhibitors probably inhibit HCV by downregulating the host Hsc70 expression. Structure-activity analysis of these compounds revealed that the double bond between C-11 and C-12 and the substituents at C-8 and C-9 are important for their activity against HCV. Conclusion: Suppression of Hsc70 expression in the host cell to limit HCV replication is a potential anti-HCV strategy. Phenanthridines are probably the HCV inhibitors with this mode of action.
资助信息National Natural Science Foundation of China [81402828, 21432010]; "Xi Bu Zhi Guang" Foundation of The Chinese Academy of Sciences
学科领域Chemistry, Medicinal
DOI10.4155/fmc.15.14
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000354104900004
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21351
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
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Chen, Duozhi,Cai, Jieyun,Yin, Junlin,et al. Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors[J]. FUTURE MEDICINAL CHEMISTRY,2015,7(5):561-570.
APA Chen, Duozhi.,Cai, Jieyun.,Yin, Junlin.,Jiang, Jiandong.,Jing, Chenxu.,...&haoxj@mail.kib.ac.cn.(2015).Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors.FUTURE MEDICINAL CHEMISTRY,7(5),561-570.
MLA Chen, Duozhi,et al."Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors".FUTURE MEDICINAL CHEMISTRY 7.5(2015):561-570.
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