| Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1 | |
Chen, Chunmei; Zhu, Hucheng; Wang, Jianping; Yang, Jing ; Li, Xiao-Nian; Wang, Jing; Chen, Keliang; Wang, Yanyan; Luo, Zengwei; Yao, Guangmin; Xue, Yongbo; Zhang, Yonghui; Xue,YB (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.; yongboxue@mail.hust.edu.cn; zhangyh@mails.tjmu.edu.cn
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| 2015-05-01 | |
| Source Publication | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
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| Issue | 14Pages:3086-3094 |
| Abstract | Eight rare pyrrole-based cytochalasans, termed armochaetoglobins K-R (1-8), along with three known analogues (9-11), were isolated from the solid culture broth of Chaetomium globosum TW1-1, a symbiotic fungus derived from the medicinal terrestrial arthropod Armadillidium vulgare. Their structures were elucidated using a combination of spectroscopic analysis, a single-crystal X-ray diffraction experiment, and an electronic circular dichroism (ECD) calculation. Compounds 4-8 represent the first examples of chaetoglobosin-type cytochalasans with an sp(3) methine carbon at C-18. All of the isolates were evaluated for their anti-HIV activities in vitro, and compounds 2-4, 7, 8, and 10 showed significant anti-HIV activities, with EC50 values ranging from 0.11 to 0.55 mu M, and selectivity index (SI) values ranging from 12.33 to 75.42. A plausible biosynthetic pathway was proposed to explain the origin of the pyrrole ring. |
| Keyword | Natural Products Drug Discovery Antiviral Agents Polycycles Structure Elucidation |
| Subject Area | Chemistry, Organic |
| DOI | 10.1002/ejoc.201403678 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000354212000015 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/21350 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Xue,YB (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.; yongboxue@mail.hust.edu.cn; zhangyh@mails.tjmu.edu.cn |
| Recommended Citation GB/T 7714 | Chen, Chunmei,Zhu, Hucheng,Wang, Jianping,et al. Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015(14):3086-3094. |
| APA | Chen, Chunmei.,Zhu, Hucheng.,Wang, Jianping.,Yang, Jing.,Li, Xiao-Nian.,...&zhangyh@mails.tjmu.edu.cn.(2015).Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(14),3086-3094. |
| MLA | Chen, Chunmei,et al."Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .14(2015):3086-3094. |
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| chen2015 (1).pdf（5556KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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