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题名: Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1
作者: Chen, Chunmei; Zhu, Hucheng; Wang, Jianping; Yang, Jing; Li, Xiao-Nian; Wang, Jing; Chen, Keliang; Wang, Yanyan; Luo, Zengwei; Yao, Guangmin; Xue, Yongbo; Zhang, Yonghui
刊名: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
关键词: Natural products ; Drug discovery ; Antiviral agents ; Polycycles ; Structure elucidation
英文摘要: Eight rare pyrrole-based cytochalasans, termed armochaetoglobins K-R (1-8), along with three known analogues (9-11), were isolated from the solid culture broth of Chaetomium globosum TW1-1, a symbiotic fungus derived from the medicinal terrestrial arthropod Armadillidium vulgare. Their structures were elucidated using a combination of spectroscopic analysis, a single-crystal X-ray diffraction experiment, and an electronic circular dichroism (ECD) calculation. Compounds 4-8 represent the first examples of chaetoglobosin-type cytochalasans with an sp(3) methine carbon at C-18. All of the isolates were evaluated for their anti-HIV activities in vitro, and compounds 2-4, 7, 8, and 10 showed significant anti-HIV activities, with EC50 values ranging from 0.11 to 0.55 mu M, and selectivity index (SI) values ranging from 12.33 to 75.42. A plausible biosynthetic pathway was proposed to explain the origin of the pyrrole ring.
出版日期: 2015-05-01
期号: 14, 页码:3086-3094
语种: 英语
收录类别: SCI
学科分类: Chemistry, Organic
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21350
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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