Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1
Chen, Chunmei; Zhu, Hucheng; Wang, Jianping; Yang, Jing; Li, Xiao-Nian; Wang, Jing; Chen, Keliang; Wang, Yanyan; Luo, Zengwei; Yao, Guangmin; Xue, Yongbo; Zhang, Yonghui; Xue,YB (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.; yongboxue@mail.hust.edu.cn; zhangyh@mails.tjmu.edu.cn
2015-05-01
发表期刊EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
期号14页码:3086-3094
摘要Eight rare pyrrole-based cytochalasans, termed armochaetoglobins K-R (1-8), along with three known analogues (9-11), were isolated from the solid culture broth of Chaetomium globosum TW1-1, a symbiotic fungus derived from the medicinal terrestrial arthropod Armadillidium vulgare. Their structures were elucidated using a combination of spectroscopic analysis, a single-crystal X-ray diffraction experiment, and an electronic circular dichroism (ECD) calculation. Compounds 4-8 represent the first examples of chaetoglobosin-type cytochalasans with an sp(3) methine carbon at C-18. All of the isolates were evaluated for their anti-HIV activities in vitro, and compounds 2-4, 7, 8, and 10 showed significant anti-HIV activities, with EC50 values ranging from 0.11 to 0.55 mu M, and selectivity index (SI) values ranging from 12.33 to 75.42. A plausible biosynthetic pathway was proposed to explain the origin of the pyrrole ring.
关键词Natural Products Drug Discovery Antiviral Agents Polycycles Structure Elucidation
资助信息State Education Ministry of China, Program for New Century Excellent Talents in University [NCET-2008-0224]; National Natural Science Foundation of China (NSFC) [31370372, 31200258, 31270395, 81202423]; National Science and Technology Project of China [2011ZX09102-004]
学科领域Chemistry, Organic
DOI10.1002/ejoc.201403678
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000354212000015
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21350
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Xue,YB (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.; yongboxue@mail.hust.edu.cn; zhangyh@mails.tjmu.edu.cn
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Chen, Chunmei,Zhu, Hucheng,Wang, Jianping,et al. Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2015(14):3086-3094.
APA Chen, Chunmei.,Zhu, Hucheng.,Wang, Jianping.,Yang, Jing.,Li, Xiao-Nian.,...&zhangyh@mails.tjmu.edu.cn.(2015).Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(14),3086-3094.
MLA Chen, Chunmei,et al."Armochaetoglobins K-R, Anti-HIV Pyrrole-Based Cytochalasans from Chaetomium globosum TW1-1".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .14(2015):3086-3094.
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