| Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora | |
Fan, Yi-Min1,2; Yi, Ping1,2; Li, Yang3; Yan, Chen1,2; Huang, Tao1,2; Gu, Wei1,2 ; Ma, Yuan1,2; Huang, Lie-Jun1,2; Zhang, Jian-Xin1,2; Yang, Chong-Lin3; Li, Yan4; Yuan, Chun-Mao1,2; Hao, Xiao-Jiang1,2,4; Yuan,CM (reprint author),Key Lab Chem Nat Prod Guizhou Prov,Guiyang 550002,Peoples R China.; yuanchunmao01@126.com; haoxj@mail.kib.ac.cn
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| 2015-05-01 | |
| 发表期刊 | ORGANIC LETTERS
 |
| 卷号 | 17期号:9页码:2066-2069 |
| 摘要 | Two polycyclic polyprenylated acylphloroglucinols, garcimulins A and B ((+/-)-1 and 2), including a pair of enantiomers with the unique caged tetracyclo[5.4.1.1(1,5).0(9,13)]tridecane skeleton were isolated from Garcinia multiflora. Their structures and absolute configurations were determined by extensive analysis of spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 exhibited cytotoxic activities against five human cancer cell lines in vitro (IC50 3.42-13.23 mu M). The acidification of lysosomes in HeLa cell was obviously affected by compound 2. |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1021/acs.orglett.5b00588 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354004400008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/21343 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Yuan,CM (reprint author),Key Lab Chem Nat Prod Guizhou Prov,Guiyang 550002,Peoples R China.; yuanchunmao01@126.com; haoxj@mail.kib.ac.cn |
| 作者单位 | 1.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China 2.Chinese Acad Sci, Guiyang 550002, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Yi-Min,Yi, Ping,Li, Yang,et al. Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora[J]. ORGANIC LETTERS,2015,17(9):2066-2069. |
| APA | Fan, Yi-Min.,Yi, Ping.,Li, Yang.,Yan, Chen.,Huang, Tao.,...&haoxj@mail.kib.ac.cn.(2015).Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora.ORGANIC LETTERS,17(9),2066-2069. |
| MLA | Fan, Yi-Min,et al."Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora".ORGANIC LETTERS 17.9(2015):2066-2069. |
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