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题名: Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora
作者: Fan, Yi-Min1, 2; Yi, Ping1, 2; Li, Yang3; Yan, Chen1, 2; Huang, Tao1, 2; Gu, Wei1, 2; Ma, Yuan1, 2; Huang, Lie-Jun1, 2; Zhang, Jian-Xin1, 2; Yang, Chong-Lin3; null(李艳)4; Yuan, Chun-Mao1, 2; null(郝小江)1, 2, 4
刊名: ORGANIC LETTERS
出版日期: 2015-05-01
卷号: 17, 期号:9, 页码:2066-2069
学科分类: Chemistry, Organic
DOI: 10.1021/acs.orglett.5b00588
通讯作者: Yuan,CM (reprint author),Key Lab Chem Nat Prod Guizhou Prov,Guiyang 550002,Peoples R China. ; yuanchunmao01@126.com ; haoxj@mail.kib.ac.cn
文章类型: Article
英文摘要: Two polycyclic polyprenylated acylphloroglucinols, garcimulins A and B ((+/-)-1 and 2), including a pair of enantiomers with the unique caged tetracyclo[5.4.1.1(1,5).0(9,13)]tridecane skeleton were isolated from Garcinia multiflora. Their structures and absolute configurations were determined by extensive analysis of spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 exhibited cytotoxic activities against five human cancer cell lines in vitro (IC50 3.42-13.23 mu M). The acidification of lysosomes in HeLa cell was obviously affected by compound 2.
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: CANCER ; DERIVATIVES ; INHIBITION ; AUTOPHAGY
收录类别: SCI
项目资助者: Scientific and Technological Planning Project of Guizhou [QKH-NZ (2011) 3002] ; Modernization of Traditional Chinese Medicine [QKH-NZ (2011) 5085] ; Talent Base Construction Funds (Starting Fund) [112]
语种: 英语
WOS记录号: WOS:000354004400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21343
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
2.Chinese Acad Sci, Guiyang 550002, Peoples R China
3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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