Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora
Fan, Yi-Min1,2; Yi, Ping1,2; Li, Yang3; Yan, Chen1,2; Huang, Tao1,2; Gu, Wei1,2; Ma, Yuan1,2; Huang, Lie-Jun1,2; Zhang, Jian-Xin1,2; Yang, Chong-Lin3; Li, Yan4; Yuan, Chun-Mao1,2; Hao, Xiao-Jiang1,2,4; Yuan,CM (reprint author),Key Lab Chem Nat Prod Guizhou Prov,Guiyang 550002,Peoples R China.; yuanchunmao01@126.com; haoxj@mail.kib.ac.cn
2015-05-01
发表期刊ORGANIC LETTERS
卷号17期号:9页码:2066-2069
摘要Two polycyclic polyprenylated acylphloroglucinols, garcimulins A and B ((+/-)-1 and 2), including a pair of enantiomers with the unique caged tetracyclo[5.4.1.1(1,5).0(9,13)]tridecane skeleton were isolated from Garcinia multiflora. Their structures and absolute configurations were determined by extensive analysis of spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 exhibited cytotoxic activities against five human cancer cell lines in vitro (IC50 3.42-13.23 mu M). The acidification of lysosomes in HeLa cell was obviously affected by compound 2.
资助信息Scientific and Technological Planning Project of Guizhou [QKH-NZ (2011) 3002]; Modernization of Traditional Chinese Medicine [QKH-NZ (2011) 5085]; Talent Base Construction Funds (Starting Fund) [112]
学科领域Chemistry, Organic
DOI10.1021/acs.orglett.5b00588
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000354004400008
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21343
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Yuan,CM (reprint author),Key Lab Chem Nat Prod Guizhou Prov,Guiyang 550002,Peoples R China.; yuanchunmao01@126.com; haoxj@mail.kib.ac.cn
作者单位1.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
2.Chinese Acad Sci, Guiyang 550002, Peoples R China
3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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GB/T 7714
Fan, Yi-Min,Yi, Ping,Li, Yang,et al. Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora[J]. ORGANIC LETTERS,2015,17(9):2066-2069.
APA Fan, Yi-Min.,Yi, Ping.,Li, Yang.,Yan, Chen.,Huang, Tao.,...&haoxj@mail.kib.ac.cn.(2015).Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora.ORGANIC LETTERS,17(9),2066-2069.
MLA Fan, Yi-Min,et al."Two Unusual Polycyclic Polyprenylated Acylphloroglucinols, Including a Pair of Enantiomers from Garcinia multiflora".ORGANIC LETTERS 17.9(2015):2066-2069.
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