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题名: Bioactive Limonoid Constituents of Munronia henryi
作者: Yan, Ying1, 2, 3; Zhang, Jian-Xin1, 2; Huang, Tao1, 2; Mao, Xin-Ying1, 2; Gu, Wei1, 2; He, Hong-Ping4; Di, Ying-Tong4; Li, Shun-Lin4; Chen, Duo-Zhi4; Zhang, Yu4; null(郝小江)1, 2
刊名: JOURNAL OF NATURAL PRODUCTS
出版日期: 2015-04-01
卷号: 78, 期号:4, 页码:811-821
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
DOI: 10.1021/np501057f
通讯作者: Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West,Kunming 650201,Yunnan,Peoples R China. ; zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
文章类型: Article
英文摘要: Fourteen new limonoids, munronins A-N (1-14), and eight known limonoids (15-22) were isolated from the whole plants of Munronia henryi. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry, and the structure of 8 was confirmed by single-crystal X-ray diffraction analysis. Compound 1 represents the first limonoid found with a novel 7-oxabicyclo[2.2.1]heptane moiety produced by incorporating C-11 and C-14 via an oxygen atom. All compounds were evaluated for their anti-tobacco mosaic virus (TMV) activity and in vitro cytotoxicity against the human cancer HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Among them, compounds 2, 8, 9, 10, 11, 12, 18, and 20 showed significant anti-TMV activity, with IC50 values in the range 19.6-44.4 mu g/mL. Compounds 1 and 18 exhibited cytotoxic effects for all five cancer cell lines, with IC50 values between 0.4 and 4.8 mu M.
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: MELIA-TOOSENDAN ; MOSAIC-VIRUS ; APHANAMIXIS-POLYSTACHYA ; UNIFOLIOLATA OLIV ; A-J ; DITERPENOIDS ; PRIEURIANIN ; CHEMISTRY ; LEAVES
收录类别: SCI
项目资助者: National Natural Science Foundation of China [31160374] ; Youth Innovation Promotion Association, CAS [2015323] ; National Key Scientific Instrument Development Projects of China [2011YQ12003506] ; Scientific and Technological Planning Project of Guizhou [QKH-ZY[2013] 3015]
语种: 英语
WOS记录号: WOS:000353665100028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21340
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
2.Chinese Acad Sci, Guiyang 550002, Peoples R China
3.Guizhou Univ, Ctr Res & Dev Fine Chem, Guiyang 550025, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650201, Yunnan, Peoples R China
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