Bioactive Limonoid Constituents of Munronia henryi
Yan, Ying1,2,3; Zhang, Jian-Xin1,2; Huang, Tao1,2; Mao, Xin-Ying1,2; Gu, Wei1,2; He, Hong-Ping4; Di, Ying-Tong4; Li, Shun-Lin4; Chen, Duo-Zhi4; Zhang, Yu4; Hao, Xiao-Jiang1,2; Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West,Kunming 650201,Yunnan,Peoples R China.; zhangyu@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
2015-04-01
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号78期号:4页码:811-821
摘要Fourteen new limonoids, munronins A-N (1-14), and eight known limonoids (15-22) were isolated from the whole plants of Munronia henryi. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry, and the structure of 8 was confirmed by single-crystal X-ray diffraction analysis. Compound 1 represents the first limonoid found with a novel 7-oxabicyclo[2.2.1]heptane moiety produced by incorporating C-11 and C-14 via an oxygen atom. All compounds were evaluated for their anti-tobacco mosaic virus (TMV) activity and in vitro cytotoxicity against the human cancer HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Among them, compounds 2, 8, 9, 10, 11, 12, 18, and 20 showed significant anti-TMV activity, with IC50 values in the range 19.6-44.4 mu g/mL. Compounds 1 and 18 exhibited cytotoxic effects for all five cancer cell lines, with IC50 values between 0.4 and 4.8 mu M.
资助信息National Natural Science Foundation of China [31160374]; Youth Innovation Promotion Association, CAS [2015323]; National Key Scientific Instrument Development Projects of China [2011YQ12003506]; Scientific and Technological Planning Project of Guizhou [QKH-ZY[2013] 3015]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np501057f
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000353665100028
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21340
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West,Kunming 650201,Yunnan,Peoples R China.; zhangyu@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
作者单位1.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
2.Chinese Acad Sci, Guiyang 550002, Peoples R China
3.Guizhou Univ, Ctr Res & Dev Fine Chem, Guiyang 550025, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650201, Yunnan, Peoples R China
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GB/T 7714
Yan, Ying,Zhang, Jian-Xin,Huang, Tao,et al. Bioactive Limonoid Constituents of Munronia henryi[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(4):811-821.
APA Yan, Ying.,Zhang, Jian-Xin.,Huang, Tao.,Mao, Xin-Ying.,Gu, Wei.,...&haoxj@mail.kib.ac.cn.(2015).Bioactive Limonoid Constituents of Munronia henryi.JOURNAL OF NATURAL PRODUCTS,78(4),811-821.
MLA Yan, Ying,et al."Bioactive Limonoid Constituents of Munronia henryi".JOURNAL OF NATURAL PRODUCTS 78.4(2015):811-821.
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