Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris
Qin, Xu-Jie1,2; Zhao, Yun-Li1; Lunga, Paul-Keilah1; Yang, Xing-Wei1; Song, Chang-Wei1; Cheng, Gui-Guang1; Liu, Lu1,2; Chen, Ying-Ying1,2; Liu, Ya-Ping1; Luo, Xiao-Dong1
2015-06-24
发表期刊TETRAHEDRON
卷号71期号:25页码:4372-4378
摘要

Eleven new indole alkaloids, alstoniascholarines A-K (1-11), along with one known analogue, were isolated from the aqueous fraction of Alstonia scholaris leaf extract. Their structures were established on the basis of extensive spectroscopic data analysis, chemical transformation, and quantum theory. Alkaloid 4 possessed a novel skeleton with fused-ring and a six-membered ring, the absolute configuration of which was assigned by quantum theory. Alkaloids 6 and 10 showed the best antibacterial activity against Pseudomonas aeruginosa with an MIC value of 3.13 mu g/mL. (C) 2015 Elsevier Ltd. All rights reserved.

关键词Apocynaceae Alstonia Scholaris Indole Alkaloid Antibacterial Activity
资助信息National Natural Science Foundation of China [81225024, 31170334]; Ministry of Science and Technology of China [2014ZX09301307-003]; Chinese Academy of Sciences [KSZD-EW-Z-004-03]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21337
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Liu, Ya-Ping; Luo, Xiao-Dong
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Qin, Xu-Jie,Zhao, Yun-Li,Lunga, Paul-Keilah,et al. Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris[J]. TETRAHEDRON,2015,71(25):4372-4378.
APA Qin, Xu-Jie.,Zhao, Yun-Li.,Lunga, Paul-Keilah.,Yang, Xing-Wei.,Song, Chang-Wei.,...&Luo, Xiao-Dong.(2015).Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris.TETRAHEDRON,71(25),4372-4378.
MLA Qin, Xu-Jie,et al."Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris".TETRAHEDRON 71.25(2015):4372-4378.
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