Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris
Qin, Xu-Jie1,2; Zhao, Yun-Li1; Lunga, Paul-Keilah1; Yang, Xing-Wei1; Song, Chang-Wei1; Cheng, Gui-Guang1; Liu, Lu1,2; Chen, Ying-Ying1,2; Liu, Ya-Ping1; Luo, Xiao-Dong1
2015-06-24
Source PublicationTETRAHEDRON
Volume71Issue:25Pages:4372-4378
Abstract

Eleven new indole alkaloids, alstoniascholarines A-K (1-11), along with one known analogue, were isolated from the aqueous fraction of Alstonia scholaris leaf extract. Their structures were established on the basis of extensive spectroscopic data analysis, chemical transformation, and quantum theory. Alkaloid 4 possessed a novel skeleton with fused-ring and a six-membered ring, the absolute configuration of which was assigned by quantum theory. Alkaloids 6 and 10 showed the best antibacterial activity against Pseudomonas aeruginosa with an MIC value of 3.13 mu g/mL. (C) 2015 Elsevier Ltd. All rights reserved.

KeywordApocynaceae Alstonia Scholaris Indole Alkaloid Antibacterial Activity
Subject AreaChemistry, Organic
DOI10.1016/j.tet.2015.04.046
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000356111100012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/21337
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLiu, Ya-Ping; Luo, Xiao-Dong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Qin, Xu-Jie,Zhao, Yun-Li,Lunga, Paul-Keilah,et al. Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris[J]. TETRAHEDRON,2015,71(25):4372-4378.
APA Qin, Xu-Jie.,Zhao, Yun-Li.,Lunga, Paul-Keilah.,Yang, Xing-Wei.,Song, Chang-Wei.,...&Luo, Xiao-Dong.(2015).Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris.TETRAHEDRON,71(25),4372-4378.
MLA Qin, Xu-Jie,et al."Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris".TETRAHEDRON 71.25(2015):4372-4378.
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