Synthesis and cytotoxicity of some new eriocalyxin B derivatives
Zhao, Yu; Niu, Xue-Mei; Qian, Li-Ping; Liu, Ze-Yuan; Zhao, Qin-Shi; Sun, Han-Dong
AbstractEriocalyxin B (1) was regarded as the promising candidate for new anticancer agent because of its potent activity and novel mechanism of action. Systematic modifications of 1 were done, and nineteen derivatives were synthesized and their cytotoxicities against five tumor cell lines were evaluated. The structure-activity relationship (SAR) of 1 confirmed that the alpha,beta-unsaturated ketone moieties in ring A and D are the leading active sites; the 7,20-epoxy moiety, OH-6 and OH-7 play an important role in keeping the cytotoxicity. The 6,7-seco derivative 19 had remarkable activity while derivative 20 oxidized from 19 was completely inactive, which suggested that the carboxyl group could destroy the cytoxicity of 20 despite the presence of alpha,beta-unsaturated ketone moiety. (c) 2006 Elsevier Masson SAS. All rights reserved.
KeywordEriocalyxin b Synthesis Cytotoxicity Sar
Subject AreaChemistry ; Medicinal
Indexed BySCI ; IC
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000246268500009
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Acad Mil Med Sci, Affiliated Hosp, Dept Clin Pharmacol, Beijing 100039, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Yu,Niu, Xue-Mei,Qian, Li-Ping,et al. Synthesis and cytotoxicity of some new eriocalyxin B derivatives[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2007,42(4):494-502.
APA Zhao, Yu,Niu, Xue-Mei,Qian, Li-Ping,Liu, Ze-Yuan,Zhao, Qin-Shi,&Sun, Han-Dong.(2007).Synthesis and cytotoxicity of some new eriocalyxin B derivatives.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,42(4),494-502.
MLA Zhao, Yu,et al."Synthesis and cytotoxicity of some new eriocalyxin B derivatives".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 42.4(2007):494-502.
Files in This Item: Download All
File Name/Size DocType Version Access License
201109210006.pdf(329KB) 开放获取--View Download
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhao, Yu]'s Articles
[Niu, Xue-Mei]'s Articles
[Qian, Li-Ping]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao, Yu]'s Articles
[Niu, Xue-Mei]'s Articles
[Qian, Li-Ping]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao, Yu]'s Articles
[Niu, Xue-Mei]'s Articles
[Qian, Li-Ping]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 201109210006.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.