Synthesis and cytotoxicity of some new eriocalyxin B derivatives
Zhao, Yu; Niu, Xue-Mei; Qian, Li-Ping; Liu, Ze-Yuan; Zhao, Qin-Shi; Sun, Han-Dong
2007-04-01
发表期刊EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN0223-5234
卷号42期号:4页码:494-502
摘要Eriocalyxin B (1) was regarded as the promising candidate for new anticancer agent because of its potent activity and novel mechanism of action. Systematic modifications of 1 were done, and nineteen derivatives were synthesized and their cytotoxicities against five tumor cell lines were evaluated. The structure-activity relationship (SAR) of 1 confirmed that the alpha,beta-unsaturated ketone moieties in ring A and D are the leading active sites; the 7,20-epoxy moiety, OH-6 and OH-7 play an important role in keeping the cytotoxicity. The 6,7-seco derivative 19 had remarkable activity while derivative 20 oxidized from 19 was completely inactive, which suggested that the carboxyl group could destroy the cytoxicity of 20 despite the presence of alpha,beta-unsaturated ketone moiety. (c) 2006 Elsevier Masson SAS. All rights reserved.
关键词Eriocalyxin b Synthesis Cytotoxicity Sar
学科领域Chemistry ; Medicinal
DOI10.1016/j.ejmech.2006.11.004
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000246268500009
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2093
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Acad Mil Med Sci, Affiliated Hosp, Dept Clin Pharmacol, Beijing 100039, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Yu,Niu, Xue-Mei,Qian, Li-Ping,et al. Synthesis and cytotoxicity of some new eriocalyxin B derivatives[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2007,42(4):494-502.
APA Zhao, Yu,Niu, Xue-Mei,Qian, Li-Ping,Liu, Ze-Yuan,Zhao, Qin-Shi,&Sun, Han-Dong.(2007).Synthesis and cytotoxicity of some new eriocalyxin B derivatives.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,42(4),494-502.
MLA Zhao, Yu,et al."Synthesis and cytotoxicity of some new eriocalyxin B derivatives".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 42.4(2007):494-502.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
201109210006.pdf(329KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Yu]的文章
[Niu, Xue-Mei]的文章
[Qian, Li-Ping]的文章
百度学术
百度学术中相似的文章
[Zhao, Yu]的文章
[Niu, Xue-Mei]的文章
[Qian, Li-Ping]的文章
必应学术
必应学术中相似的文章
[Zhao, Yu]的文章
[Niu, Xue-Mei]的文章
[Qian, Li-Ping]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。