| Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor | |
| Zhou, Min1,2,3; Du, Gang1,2; Yang, Hai-Ying1,2; Xia, Cong-Fang1,2; Yang, Juan-Xia1,2; Ye, Yan-qing1,2; Gao, Xue-Mei1,2; Li, Xiao-Nian3; Hu, Qiu-Fen1,2; Li,XN (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Lanhei Rd 132,Kunming 650201,Peoples R China.; lixiaonian@mail.kib.ac.cn; huqiufena@aliyun.com | |
| 2015-02-01 | |
| Source Publication | PLANTA MEDICA
 |
| Volume | 81Issue:3Pages:235-240 |
| Abstract | Versicolactones A-D (1-4), four new butyrolactones, along with four known butyrolactones (5-8) were isolated from the fermentation products of the endophytic fungus Aspergillus versicolor. The structures of compounds 1-4, including absolute configuration, were elucidated by interpretation of the NMR and CD data. Compound 2 was further confirmed by single-crystal X-ray diffraction analysis. In particular, compound 1 is the first naturally occurring butyrolactone possessing an unusual 2-oxopropyl group. More importantly, compounds 1 and 8 displayed significant antitobacco mosaic virus activities with inhibition rates of 46.4% and 35.4%, even more potent than the positive control ningnanmycin (30.8%). Compound 1 also showed moderate cytotoxicity against A549 and MCF7 cells with IC50 values of 3.2 and 2.5 mu M, respectively. |
| Keyword | Aspergillus Versicolor Butyrolactones Trichocomaceae Antitobacco Mosaic Virus Activity Cytotoxicity |
| Subject Area | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1055/s-0034-1396153 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000350223500009 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/20628 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Li,XN (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Lanhei Rd 132,Kunming 650201,Peoples R China.; lixiaonian@mail.kib.ac.cn; huqiufena@aliyun.com |
| Affiliation | 1.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China 2.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China 3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China |
| Recommended Citation GB/T 7714 | Zhou, Min,Du, Gang,Yang, Hai-Ying,et al. Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor[J]. PLANTA MEDICA,2015,81(3):235-240. |
| APA | Zhou, Min.,Du, Gang.,Yang, Hai-Ying.,Xia, Cong-Fang.,Yang, Juan-Xia.,...&huqiufena@aliyun.com.(2015).Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor.PLANTA MEDICA,81(3),235-240. |
| MLA | Zhou, Min,et al."Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor".PLANTA MEDICA 81.3(2015):235-240. |
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