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题名: Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor
作者: Zhou, Min1, 2, 3; Du, Gang1, 2; Yang, Hai-Ying1, 2; Xia, Cong-Fang1, 2; Yang, Juan-Xia1, 2; Ye, Yan-qing1, 2; Gao, Xue-Mei1, 2; Li, Xiao-Nian3; Hu, Qiu-Fen1, 2
刊名: PLANTA MEDICA
关键词: Aspergillus versicolor ; butyrolactones ; Trichocomaceae ; antitobacco mosaic virus activity ; cytotoxicity
英文摘要: Versicolactones A-D (1-4), four new butyrolactones, along with four known butyrolactones (5-8) were isolated from the fermentation products of the endophytic fungus Aspergillus versicolor. The structures of compounds 1-4, including absolute configuration, were elucidated by interpretation of the NMR and CD data. Compound 2 was further confirmed by single-crystal X-ray diffraction analysis. In particular, compound 1 is the first naturally occurring butyrolactone possessing an unusual 2-oxopropyl group. More importantly, compounds 1 and 8 displayed significant antitobacco mosaic virus activities with inhibition rates of 46.4% and 35.4%, even more potent than the positive control ningnanmycin (30.8%). Compound 1 also showed moderate cytotoxicity against A549 and MCF7 cells with IC50 values of 3.2 and 2.5 mu M, respectively.
出版日期: 2015-02-01
卷号: 81, 期号:3, 页码:235-240
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20628
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
2.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
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