Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor
Zhou, Min1,2,3; Du, Gang1,2; Yang, Hai-Ying1,2; Xia, Cong-Fang1,2; Yang, Juan-Xia1,2; Ye, Yan-qing1,2; Gao, Xue-Mei1,2; Li, Xiao-Nian3; Hu, Qiu-Fen1,2; Li,XN (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Lanhei Rd 132,Kunming 650201,Peoples R China.; lixiaonian@mail.kib.ac.cn; huqiufena@aliyun.com
2015-02-01
发表期刊PLANTA MEDICA
卷号81期号:3页码:235-240
摘要Versicolactones A-D (1-4), four new butyrolactones, along with four known butyrolactones (5-8) were isolated from the fermentation products of the endophytic fungus Aspergillus versicolor. The structures of compounds 1-4, including absolute configuration, were elucidated by interpretation of the NMR and CD data. Compound 2 was further confirmed by single-crystal X-ray diffraction analysis. In particular, compound 1 is the first naturally occurring butyrolactone possessing an unusual 2-oxopropyl group. More importantly, compounds 1 and 8 displayed significant antitobacco mosaic virus activities with inhibition rates of 46.4% and 35.4%, even more potent than the positive control ningnanmycin (30.8%). Compound 1 also showed moderate cytotoxicity against A549 and MCF7 cells with IC50 values of 3.2 and 2.5 mu M, respectively.
关键词Aspergillus Versicolor Butyrolactones Trichocomaceae Antitobacco Mosaic Virus Activity Cytotoxicity
资助信息National Natural Science Foundation of China [21302164]; Excellent Scientific and Technological Team of Yunnan High School [2010CI08]; Yunnan University of Nationalities Green Chemistry and Functional Materials Research for Provincial Innovation Team [2011HC008]; Yunnan University of Nationalities
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-0034-1396153
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000350223500009
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20628
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li,XN (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Lanhei Rd 132,Kunming 650201,Peoples R China.; lixiaonian@mail.kib.ac.cn; huqiufena@aliyun.com
作者单位1.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
2.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
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GB/T 7714
Zhou, Min,Du, Gang,Yang, Hai-Ying,et al. Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor[J]. PLANTA MEDICA,2015,81(3):235-240.
APA Zhou, Min.,Du, Gang.,Yang, Hai-Ying.,Xia, Cong-Fang.,Yang, Juan-Xia.,...&huqiufena@aliyun.com.(2015).Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor.PLANTA MEDICA,81(3),235-240.
MLA Zhou, Min,et al."Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor".PLANTA MEDICA 81.3(2015):235-240.
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