Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor
Zhou, Min1,2,3; Du, Gang1,2; Yang, Hai-Ying1,2; Xia, Cong-Fang1,2; Yang, Juan-Xia1,2; Ye, Yan-qing1,2; Gao, Xue-Mei1,2; Li, Xiao-Nian3; Hu, Qiu-Fen1,2; Li,XN (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Lanhei Rd 132,Kunming 650201,Peoples R China.; lixiaonian@mail.kib.ac.cn; huqiufena@aliyun.com
2015-02-01
Source PublicationPLANTA MEDICA
Volume81Issue:3Pages:235-240
AbstractVersicolactones A-D (1-4), four new butyrolactones, along with four known butyrolactones (5-8) were isolated from the fermentation products of the endophytic fungus Aspergillus versicolor. The structures of compounds 1-4, including absolute configuration, were elucidated by interpretation of the NMR and CD data. Compound 2 was further confirmed by single-crystal X-ray diffraction analysis. In particular, compound 1 is the first naturally occurring butyrolactone possessing an unusual 2-oxopropyl group. More importantly, compounds 1 and 8 displayed significant antitobacco mosaic virus activities with inhibition rates of 46.4% and 35.4%, even more potent than the positive control ningnanmycin (30.8%). Compound 1 also showed moderate cytotoxicity against A549 and MCF7 cells with IC50 values of 3.2 and 2.5 mu M, respectively.
KeywordAspergillus Versicolor Butyrolactones Trichocomaceae Antitobacco Mosaic Virus Activity Cytotoxicity
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1055/s-0034-1396153
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000350223500009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20628
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi,XN (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Lanhei Rd 132,Kunming 650201,Peoples R China.; lixiaonian@mail.kib.ac.cn; huqiufena@aliyun.com
Affiliation1.Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
2.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Min,Du, Gang,Yang, Hai-Ying,et al. Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor[J]. PLANTA MEDICA,2015,81(3):235-240.
APA Zhou, Min.,Du, Gang.,Yang, Hai-Ying.,Xia, Cong-Fang.,Yang, Juan-Xia.,...&huqiufena@aliyun.com.(2015).Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor.PLANTA MEDICA,81(3),235-240.
MLA Zhou, Min,et al."Antiviral Butyrolactones from the Endophytic Fungus Aspergillus versicolor".PLANTA MEDICA 81.3(2015):235-240.
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