Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile
Liao, Yang1,2; Liu, Xia1; Yang, Jing1; Lao, Yuan-Zhi3; Yang, Xing-Wei1,2; Li, Xiao-Nian1; Zhang, Jing-Jing1; Ding, Zhi-jie3; Xu, Hong-Xi3; Xu, Gang1
2015-03-06
发表期刊ORGANIC LETTERS
卷号17期号:5页码:1172-1175
摘要

Hypersubones A and B (1, 2), two adamantane type polycyclic polyprenylated acylphloroglucinols possessing an unprecedented seco-adamantane architecture and a tetracyclo-[6.3.1.13,10.04,8]-tridecane core combined with a peroxide ring, respectively, were isolated from Hypericum subsessile together with three analogues (3-5). Their structures were determined by extensive NMR spectroscopic analysis, ECD calculations, and single-crystal X-ray diffraction. Compound 2 exhibited significant cytotoxicities against four human cancer lines in vitro (IC50 0.07-7.52 mu M).

资助信息NSFC [20972167]; Young Academic Leader Raising Foundation of Yunnan Province [2009CI073]; National Science and Technology Support Program of China [2013BAI11B02]; CAS
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20590
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Xu, Hong-Xi; Xu, Gang
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Liao, Yang,Liu, Xia,Yang, Jing,et al. Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile[J]. ORGANIC LETTERS,2015,17(5):1172-1175.
APA Liao, Yang.,Liu, Xia.,Yang, Jing.,Lao, Yuan-Zhi.,Yang, Xing-Wei.,...&Xu, Gang.(2015).Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile.ORGANIC LETTERS,17(5),1172-1175.
MLA Liao, Yang,et al."Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile".ORGANIC LETTERS 17.5(2015):1172-1175.
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