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题名: Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile
作者: Liao, Yang1, 2; Liu, Xia1; Yang, Jing1; Lao, Yuan-Zhi3; Yang, Xing-Wei1, 2; Li, Xiao-Nian1; Zhang, Jing-Jing1; Ding, Zhi-jie3; Xu, Hong-Xi3; null(许刚)1
刊名: ORGANIC LETTERS
出版日期: 2015-03-06
卷号: 17, 期号:5, 页码:1172-1175
学科分类: Chemistry, Organic
DOI: 10.1021/acs.orglett.5b00100
通讯作者: Xu,HX (reprint author),Shanghai Univ Tradit Chinese Med,Sch Pharm,Shanghai 201203,Peoples R China. ; xuhongxi88@gmail.com ; xugang008@mail.kib.ac.cn
文章类型: Article
英文摘要: Hypersubones A and B (1, 2), two adamantane type polycyclic polyprenylated acylphloroglucinols possessing an unprecedented seco-adamantane architecture and a tetracyclo-[6.3.1.13,10.04,8]-tridecane core combined with a peroxide ring, respectively, were isolated from Hypericum subsessile together with three analogues (3-5). Their structures were determined by extensive NMR spectroscopic analysis, ECD calculations, and single-crystal X-ray diffraction. Compound 2 exhibited significant cytotoxicities against four human cancer lines in vitro (IC50 0.07-7.52 mu M).
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: POLYPRENYLATED ACYLPHLOROGLUCINOLS ; MEDICINAL CHEMISTRY ; DERIVATIVES ; SAMPSONII ; GUTTIFERAE ; ANNULATION ; SKELETON
收录类别: SCI
项目资助者: NSFC [20972167] ; Young Academic Leader Raising Foundation of Yunnan Province [2009CI073] ; National Science and Technology Support Program of China [2013BAI11B02] ; CAS
语种: 英语
WOS记录号: WOS:000350841300029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20590
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
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