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题名: Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla
作者: Jiang, Wei-Wei; Su, Jia; Wu, Xing-De; He, Juan; Peng, Li-Yan; Cheng, Xiao; null(赵勤实)
刊名: NATURAL PRODUCT RESEARCH
出版日期: 2015-05-03
卷号: 29, 期号:9, 页码:842-847
关键词: Uncaria rhynchophylla ; Rubiaceae ; alkaloids ; geissoschizine methyl ether N-oxide ; anti-AChE activity
学科分类: Chemistry, Applied; Chemistry, Medicinal
DOI: 10.1080/14786419.2014.989847
通讯作者: Zhao,QS (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China. ; qinshizhao@mail.kib.ac.cn
文章类型: Article
英文摘要: Geissoschizine methyl ether N-oxide, a new oxindole alkaloid, along with 14 known alkaloids, was isolated from the aerial part of Uncaria rhynchophylla. Their structures were identified by comprehensive spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that the new compound exhibited anti-AChE activity with IC50 value of 23.4M.
类目[WOS]: Chemistry, Applied ; Chemistry, Medicinal
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: INDOLE ALKALOIDS ; LEAVES ; PLANTS
收录类别: SCI
项目资助者: National Natural Science Foundation of China [U0932602] ; National Basic Research Program of China [973 Program] [2011CB915503]
语种: 英语
WOS记录号: WOS:000352853400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20586
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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