Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla
Jiang, Wei-Wei; Su, Jia; Wu, Xing-De; He, Juan; Peng, Li-Yan; Cheng, Xiao; Zhao, Qin-Shi; Zhao,QS (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; qinshizhao@mail.kib.ac.cn
2015-05-03
发表期刊NATURAL PRODUCT RESEARCH
卷号29期号:9页码:842-847
摘要Geissoschizine methyl ether N-oxide, a new oxindole alkaloid, along with 14 known alkaloids, was isolated from the aerial part of Uncaria rhynchophylla. Their structures were identified by comprehensive spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that the new compound exhibited anti-AChE activity with IC50 value of 23.4M.
关键词Uncaria Rhynchophylla Rubiaceae Alkaloids Geissoschizine Methyl Ether N-oxide Anti-ache Activity
资助信息National Natural Science Foundation of China [U0932602]; National Basic Research Program of China [973 Program] [2011CB915503]
学科领域Chemistry, Applied ; Chemistry, Medicinal
DOI10.1080/14786419.2014.989847
收录类别SCI
语种英语
WOS研究方向Chemistry ; Pharmacology & Pharmacy
WOS类目Chemistry, Applied ; Chemistry, Medicinal
WOS记录号WOS:000352853400010
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20586
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Zhao,QS (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; qinshizhao@mail.kib.ac.cn
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Jiang, Wei-Wei,Su, Jia,Wu, Xing-De,et al. Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla[J]. NATURAL PRODUCT RESEARCH,2015,29(9):842-847.
APA Jiang, Wei-Wei.,Su, Jia.,Wu, Xing-De.,He, Juan.,Peng, Li-Yan.,...&qinshizhao@mail.kib.ac.cn.(2015).Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla.NATURAL PRODUCT RESEARCH,29(9),842-847.
MLA Jiang, Wei-Wei,et al."Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla".NATURAL PRODUCT RESEARCH 29.9(2015):842-847.
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