Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla
Jiang, Wei-Wei; Su, Jia; Wu, Xing-De; He, Juan; Peng, Li-Yan; Cheng, Xiao; Zhao, Qin-Shi; Zhao,QS (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; qinshizhao@mail.kib.ac.cn
2015-05-03
Source PublicationNATURAL PRODUCT RESEARCH
Volume29Issue:9Pages:842-847
AbstractGeissoschizine methyl ether N-oxide, a new oxindole alkaloid, along with 14 known alkaloids, was isolated from the aerial part of Uncaria rhynchophylla. Their structures were identified by comprehensive spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that the new compound exhibited anti-AChE activity with IC50 value of 23.4M.
KeywordUncaria Rhynchophylla Rubiaceae Alkaloids Geissoschizine Methyl Ether N-oxide Anti-ache Activity
Subject AreaChemistry, Applied ; Chemistry, Medicinal
DOI10.1080/14786419.2014.989847
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000352853400010
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20586
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhao,QS (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; qinshizhao@mail.kib.ac.cn
Recommended Citation
GB/T 7714
Jiang, Wei-Wei,Su, Jia,Wu, Xing-De,et al. Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla[J]. NATURAL PRODUCT RESEARCH,2015,29(9):842-847.
APA Jiang, Wei-Wei.,Su, Jia.,Wu, Xing-De.,He, Juan.,Peng, Li-Yan.,...&qinshizhao@mail.kib.ac.cn.(2015).Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla.NATURAL PRODUCT RESEARCH,29(9),842-847.
MLA Jiang, Wei-Wei,et al."Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla".NATURAL PRODUCT RESEARCH 29.9(2015):842-847.
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