Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla

doi:10.1080/14786419.2014.989847

	Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla
	Jiang, Wei-Wei; Su, Jia; Wu, Xing-De; He, Juan; Peng, Li-Yan; Cheng, Xiao; Zhao, Qin-Shi; Zhao,QS (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; qinshizhao@mail.kib.ac.cn
	2015-05-03
发表期刊	NATURAL PRODUCT RESEARCH
卷号	29 期号:9 页码:842-847
摘要	Geissoschizine methyl ether N-oxide, a new oxindole alkaloid, along with 14 known alkaloids, was isolated from the aerial part of Uncaria rhynchophylla. Their structures were identified by comprehensive spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that the new compound exhibited anti-AChE activity with IC50 value of 23.4M.
关键词	Uncaria Rhynchophylla Rubiaceae Alkaloids Geissoschizine Methyl Ether N-oxide Anti-ache Activity
学科领域	Chemistry, Applied ; Chemistry, Medicinal
DOI	10.1080/14786419.2014.989847
收录类别	SCI
语种	英语
WOS记录号	WOS:000352853400010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/20586
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhao,QS (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; qinshizhao@mail.kib.ac.cn
推荐引用方式 GB/T 7714	Jiang, Wei-Wei,Su, Jia,Wu, Xing-De,et al. Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla[J]. NATURAL PRODUCT RESEARCH,2015,29(9):842-847.
APA	Jiang, Wei-Wei.,Su, Jia.,Wu, Xing-De.,He, Juan.,Peng, Li-Yan.,...&qinshizhao@mail.kib.ac.cn.(2015).Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla.NATURAL PRODUCT RESEARCH,29(9),842-847.
MLA	Jiang, Wei-Wei,et al."Geissoschizine methyl ether N- oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla".NATURAL PRODUCT RESEARCH 29.9(2015):842-847.

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