Seven new oxindole alkaloids, gardmutines A-F (1-6) and 18-hydroxy-chitosenine (7), along with 15 known alkaloids, were isolated from the aerial parts of Gardneria multiflora Makino. The structures of the alkaloids were established by spectroscopic methods. Alkaloids 1-6 are the first Gardneria alkaloids possessing a 7S configuration. Gardmutines D and E were cytotoxic to HeLa, MCF-7 breast, and SW-480 colon cancer cell lines. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Kunming Med Univ, Sch Publ Hlth, Kunming 650500, Peoples R China 4.Yunnan Agr Univ, Coll Hort & Landscape, Kunming 650201, Peoples R China