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题名: New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea
作者: Song, Chang-Wei1, 2; Lunga, Paul-Keilah1, 3; Qin, Xu-Jie1, 2; Cheng, Gui-Guang1, 2; Gu, Jian-Long1, 2; Liu, Ya-Ping1; Luo, Xiao-Dong1
刊名: FITOTERAPIA
出版日期: 2014-12-01
卷号: 99, 页码:267-275
关键词: Ecdysanthera rosea ; Apocynaceae ; Pregnane glycosides ; Antimicrobial activity
DOI: 10.1016/j.fitote.2014.10.008
文章类型: Article
英文摘要: Phytochemical investigation on the stem of Ecdysanthera rosea led to the isolation of eight new C-21 pregnane glycoside ecdysosides A-H (1-8), together with one known pregnane glycoside ecdysantheroside A (9). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D and 2D NMR) analysis, as well as comparison with the reported literature data. Antimicrobial activities of all the compounds were evaluated against bacteria and yeasts. Compounds 1, 9, 3 and 5 exhibited moderate antibacterial activities against respective Enterococcus faecalis and Providensia smartii, with MIC value of 12.5 mu g/mL. Compound 8 showed significant anti-yeast activity against Cryptococcus neoformans with MIC value of 12.5 mu g/mL. (C) 2014 Elsevier B.V. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CYNANCHUM-OTOPHYLLUM ; ROOTS ; PLANT
收录类别: SCI
语种: 英语
WOS记录号: WOS:000347019000034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20474
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Yaounde I, Fac Sci, Dept Biochem, Lab Phytobiochem & Med Plants Study, Yaounde, Cameroon
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