New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea
Song, Chang-Wei1,2; Lunga, Paul-Keilah1,3; Qin, Xu-Jie1,2; Cheng, Gui-Guang1,2; Gu, Jian-Long1,2; Liu, Ya-Ping1; Luo, Xiao-Dong1
2014-12-01
发表期刊FITOTERAPIA
卷号99页码:267-275
摘要Phytochemical investigation on the stem of Ecdysanthera rosea led to the isolation of eight new C-21 pregnane glycoside ecdysosides A-H (1-8), together with one known pregnane glycoside ecdysantheroside A (9). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D and 2D NMR) analysis, as well as comparison with the reported literature data. Antimicrobial activities of all the compounds were evaluated against bacteria and yeasts. Compounds 1, 9, 3 and 5 exhibited moderate antibacterial activities against respective Enterococcus faecalis and Providensia smartii, with MIC value of 12.5 mu g/mL. Compound 8 showed significant anti-yeast activity against Cryptococcus neoformans with MIC value of 12.5 mu g/mL. (C) 2014 Elsevier B.V. All rights reserved.
关键词Ecdysanthera Rosea Apocynaceae Pregnane Glycosides Antimicrobial Activity
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20474
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Yaounde I, Fac Sci, Dept Biochem, Lab Phytobiochem & Med Plants Study, Yaounde, Cameroon
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Song, Chang-Wei,Lunga, Paul-Keilah,Qin, Xu-Jie,et al. New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea[J]. FITOTERAPIA,2014,99:267-275.
APA Song, Chang-Wei.,Lunga, Paul-Keilah.,Qin, Xu-Jie.,Cheng, Gui-Guang.,Gu, Jian-Long.,...&Luo, Xiao-Dong.(2014).New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea.FITOTERAPIA,99,267-275.
MLA Song, Chang-Wei,et al."New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea".FITOTERAPIA 99(2014):267-275.
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