Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis
Bao, Ni-Man1,2; Nian, Yin1; Zhu, Guo-Lei1; Wang, Wei-Hua1; Zhou, Lin1; Qiu, Ming-Hua1,2
2014-12-01
发表期刊FITOTERAPIA
卷号99页码:191-197
摘要Six new 9,19-cycloartane triterpenes (1-6) were isolated from the aerial parts of Cimicifuga yunnanensis. The new chemical structures were determined by extensive analyses of 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first 9,19-cycloartane triterpenes characterized by CH3-18 shifting from C-13 to C-12 in the Cimicifuga spp. The evaluation of inhibition activity against human HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines indicated that compounds 1-6 showed different levels of cytotoxic activities with IC50 values ranging from 1.2 to 27.8 mu m. (C) 2014 Elsevier B.V. All rights reserved.
关键词Cimicifuga Yunnanensis 18(13 -> 12)Abeo-9 Cytotoxicity 19-cycloartane Triterpenes
DOI10.1016/j.fitote.2014.05.019
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000347019000024
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20468
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Kunming 650091, Yunnan, Peoples R China
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Bao, Ni-Man,Nian, Yin,Zhu, Guo-Lei,et al. Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis[J]. FITOTERAPIA,2014,99:191-197.
APA Bao, Ni-Man,Nian, Yin,Zhu, Guo-Lei,Wang, Wei-Hua,Zhou, Lin,&Qiu, Ming-Hua.(2014).Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis.FITOTERAPIA,99,191-197.
MLA Bao, Ni-Man,et al."Cytotoxic 9,19-cycloartane triterpenes from the aerial parts of Cimicifuga yunnanensis".FITOTERAPIA 99(2014):191-197.
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